Results 171 to 180 of about 458,494 (300)

The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi. [PDF]

PLoS Negl Trop Dis
Farah F, Fronterrè C, Taylor MJ, Forrer A.   +3 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Impact of maternal antibodies and weaning stress on the replication and transmission of human H3N2 influenza A in piglets. [PDF]

J Virol
Ciacci Zanella G, Cardenas MI, Hutter CR, Snyder CA, Wymore Brand M, Arruda B, Perez DR, Anderson TK, Rajão DS, Baker AL.   +9 more
europepmc   +1 more source

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Coverage validation survey of preventive chemotherapy for schistosomiasis in interruption of transmission districts of Ethiopia, 2025. [PDF]

Infect Dis Poverty
Churko C, Kassahun AB, Zerdo Z, Bishaw T, Kesete N, Bokicho B, Molla B, Dubale G, Atinaf H, Gebremickael A.   +9 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Malondialdehyde as a Predictor of Disease Severity and Cardiovascular Risk in Population with Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Metabolites
Lugo R, Gutiérrez-Solis AL, Jimeno-Figueroa RE, Góngora-Chan P, Vera-Aviles M, Williams-Jacquez D, Chaurand-Lara M, Valdivieso-Jimenez JA, Medina-Vera I, Guevara-Cruz M, Pacheco-Hernández B, Ix-Ruiz N, Chim-Aké R, Avila-Nava A.   +13 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Serum malondialdehyde predicts mortality in patients with acute heart failure. [PDF]

Redox Biol
Pinterić M, Klobučar I, Lechleitner M, Hofmann L, Trbušić M, Pregartner G, Berghold A, Madl T, Frank S, Degoricija V.   +9 more
europepmc   +1 more source

MDA (Methylendioxyamphetamin) [PDF]

, 2019
openaire   +1 more source