Advanced Science, EarlyView.The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo +5 more
wiley +1 more source
In vitro antitumor efficacy of hyaluronic acid coating for curcumin-loaded zeolitic imidazole frameworks-8 (ZIF-8) versus that of uncoated curcumin-loaded ZIF-8 nanocomposites. [PDF]
Sci RepOransa WW +3 more
europepmc +1 more source
A Pattern Based Model Driven Approach to Model Transformations
The OMG's Model Driven Architecture (MDA) initiative has been the focus of much attention in both academia and industry, due to its promise of more rapid and consistent software development through the increased use of models.
Appukuttan, Biju K. +4 more
core
Advanced Science, EarlyView.Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao +11 more
wiley +1 more source
Fragmentation of Long Reads Enables Reliable Mitogenome Assembly From Whole-Genome Amplification Data With Pervasive Palindromic Reads. [PDF]
Mol Ecol ResourVecchi M +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
Gender equity and social inclusion in mass drug administration for neglected tropical diseases in post-conflict South Sudan. [PDF]
Dialogues HealthRenfroe SJ +9 more
europepmc +1 more source
Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy
Advanced Science, EarlyView.A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao +11 more
wiley +1 more source
Preliminary Cold Tolerance Evaluation of Seven <i>Ilex</i> Species Based on Physiological Responses of Detached Leaves to Acute Low-Temperature Stress. [PDF]
Plants (Basel)Lu B +6 more
europepmc +1 more source
Computation Independent Representation of the Problem Domain in MDA
Objektorientēta analīze piedāvā pusformālas lietošanas gadījumu vadāmas metodes problēmas domēna modelēšanai no skaitļošanas neatkarīga skatu punkta. Piedāvātā pieeja – Topoloģiskā Funkcionēšanas Modelēšana Modeļvadāmai Arhitektūrai (TFMfMDA) palielina ...
Nazaruka, Ērika +2 more
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