Results 101 to 110 of about 5,869 (296)

Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies

Biological Research
Background Müllerian duct anomalies (MDAs) are congenital developmental disorders that present as a series of abnormalities within the reproductive tracts of females.
Shuya Chen, Yali Fan, Yujun Sun, Shenghui Li, Zhi Zheng, Chunfang Chu, Lin Li, Chenghong Yin   +7 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

ASSESSING THE RELATIONSHIP BETWEEN PROCUREMENT ETHICS AND PERSONNEL INTEGRITY IN NIGERIAN MDAs : (A STUDY OF SELECTED MDAs IN IMO STATE)

This study centres on Assessing the Relationship between Procurement Ethics and Personnel Integrity in Nigerian MDAS a case of Selected MDAS in Imo State.
OKWARA CHRISTOPHER , TOCHUKWU, OKEUDO, PROF. GERALDINE NKECHINYERE, NWADIKE, DR. E. C.   +2 more
core   +1 more source

Impact of non-surgical periodontal treatment on dental anxiety: A comparative study on patients with periodontitis

Journal of Dental Sciences
Background/purpose: Dental anxiety is prevalent and may result in the avoidance of periodontal therapy and maintenance. This study aimed to explore the impact of non-surgical periodontal treatment (NSPT) on dental anxiety among patients with ...
Jun-Chin Tu, Cheng-Yang Chiang, Hsien-Chung Chiu, Fu-Gong Lin, I-Shiang Tzeng, Earl Fu   +5 more
doaj   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Validation of the Italian Version of the Modified Dental Anxiety Scale (MDAS)

, 2010
Introduction. The management of dentally anxious patients represents a clinical challenge for the dental practitioner. Many scales have been proposed to assess dental anxiety. Among these, the MDAS showed high reliability and validity.
F. TASSINARI, S. CATAPANO, S. CARACCIOLO, N. MOBILIO, GREMIGNI, PAOLA   +4 more
core   +1 more source

MDAS - A Massive Data Analysis System

, 1997
Information based computing is the concept that scientific applications should be able to do resource and information discovery in metacomputing environments and employ semantic-based access to data.
Richard Frost, Chaitanya Baru, Richard Marciano, Michael Wan, Arcot Rajasekar, Reagan Moore   +5 more
core  

Physics‐Informed Machine Learning for Sustainable Alloy Design: Toward a Recyclable Unified Q&P Steel

Advanced Science, EarlyView.
A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei, Yong Li, Chenchong Wang, Lingyu Wang, Xiang Song, Keming Mao, Yu Zhang, Wei Xu   +7 more
wiley   +1 more source