Results 111 to 120 of about 5,869 (296)

Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation

Nature Communications, 2017
Midbrain dopaminergic neurons (mDAs) in the VTA and SNpc project to different regions and form distinct circuits. Here the authors show that transcription factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic ...
Audrey Chabrat, Guillaume Brisson, Hélène Doucet-Beaupré, Charleen Salesse, Marcos Schaan Profes, Axelle Dovonou, Cléophace Akitegetse, Julien Charest, Suzanne Lemstra, Daniel Côté, R. Jeroen Pasterkamp, Monica I. Abrudan, Emmanouil Metzakopian, Siew-Lan Ang, Martin Lévesque   +14 more
doaj   +1 more source

Identification of functional MDAs for nine complex human diseases by co-considering direct and indirect interactions.

, 2015
Highly plausible MDAs were highlighted. COPD: chronic obstructive pulmonary disease.
Xiaodan Chu (785721), Yang Wang (5921), Huiying Li (117255), Qiang Li (8118), Qian Liu (135614), Yilei Zhao (352409), Yan Li (23143), Xiaomeng Cui (785719), Wenliang Zhu (205320), Dandan Yuan (403064), Suangjiu Hu (785720)   +10 more
core   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Impact of Dental Anxiety on the Dental Health Status of Nepali Adult Patients

Clinical and Experimental Dental Research
Background Patients with high dental anxiety are found to visit dental offices less frequently and have a higher number of severely diseased teeth so they are at a greater need for intensive oral care and rehabilitation.
Tanuja Singh, Tika R. Ghimire, Manoj Dhungana   +2 more
doaj   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Reduction of MF prevalence after 3 annual MDAs for LF in Sierra Leone 2008–2010.

, 2013
Reduction of MF prevalence after 3 annual MDAs for LF in Sierra Leone 2008–2010.
Moses J. Bockarie (105527), Joseph B. Koroma (157579), Mary H. Hodges (157566), Santigie Sesay (421794), Mustapha Sonnie (157581), Yaobi Zhang (35315), Foday Sahr (236719)   +6 more
core   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Reduction of positive-only mf density after 3 annual LF MDAs in Sierra Leone 2008–2010.

, 2013
Reduction of positive-only mf density after 3 annual LF MDAs in Sierra Leone 2008–2010.
Moses J. Bockarie (105527), Joseph B. Koroma (157579), Mary H. Hodges (157566), Santigie Sesay (421794), Mustapha Sonnie (157581), Yaobi Zhang (35315), Foday Sahr (236719)   +6 more
core   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Reduction of entire-population mf density after 3 annual LF MDAs in Sierra Leone 2008–2010.

, 2013
Reduction of entire-population mf density after 3 annual LF MDAs in Sierra Leone 2008–2010.
Moses J. Bockarie (105527), Joseph B. Koroma (157579), Mary H. Hodges (157566), Santigie Sesay (421794), Mustapha Sonnie (157581), Yaobi Zhang (35315), Foday Sahr (236719)   +6 more
core   +1 more source