Results 31 to 40 of about 37,729 (256)

MDX-MYCIN: The MDX paradigm applied to the mycin domain

Computers & Mathematics with Applications, 1985
AbstractComparison of different approaches to expert system design for a given task, such as diagnosis, is difficult since they are eoften embodied in systems for domains with very different characteristics. It is a priori difficult to decide if a given difference in the approaches is necessitated by the differences in the domain. For example, it might
Jack W. Smith, Jon Sticklen, John R. Svirbely, B. Chadrasekaran   +3 more
openaire   +2 more sources

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic [PDF]

, 2018
A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity
Aartsma-Rus, A., Bogdanik, L, Davies, K, De Luca, A, Demonbruen, Ar, Duan, D, Elsey, D, Fukada, Si, Girgenrath, M, Gonzalez, Jp, Gordish-Dressman, H, Grounds, Md, Heydemann, A, Kreibich, A, Lutz, C, Nagaraju, K, Nichols, A, Partridge, T, Passini, M, Pazze, Ld, Sanarica, F, Schnell, Fj, Spencer, M, Spurney, C, van Putten, M, Wells, Dj, Willmann, R, Yokota, T, Young, Cs, Zhong, Z   +29 more
core   +3 more sources

Autotransplantation in mdx Mice of mdx Myoblasts Genetically Corrected by an HSV-1 Amplicon Vector [PDF]

Cell Transplantation, 2002
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder, characterized by a lack of dystrophin. To eliminate the need for immunosuppressive drugs, transplantation of genetically modified autologous myoblasts has been proposed as a possible therapy for this myopathy.
Santwana Mukherjee, Nicolas Caron, Goeffrey Camiran, Jacques P. Tremblay, Mathieu Bujold, Yaming Wang, Paul D. Allen   +6 more
openaire   +4 more sources

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications.
Ball, V, Betts, C A, Gait, M J, Godfrey, C, Hammond, S M, Healicon, R, Manzano, R, McClorey, G, Merritt, T M, Muses, S, O'Donovan, L, Tyler, D, Wells, D J, Wells, K E, Westering, T, Wood, M J   +15 more
core   +2 more sources

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice [PDF]

, 2015
Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the
Berardinelli, Maria Grazia, Camilli, Carlotta, Catizone, Angela, De Benedetti, Fabrizio, Forcina, Laura, Musarò, Antonio, Nicoletti, Carmine, Pelosi, Laura, Rizzuto, Emanuele, Spelta, Elisa, Testa, Erika   +10 more
core   +2 more sources

Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression. [PDF]

, 2014
Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz ...
A Gur, A Stergioulas, AP Gautam, B Hegedus, BJ Barber, CF Rizzi, CR Hayworth, D Avni, DE Lebel, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, Ernesto Cesar Pinto Leal-Junior, F Aimbire, F Aimbire, F Serra, GD Thomas, GF Cox, JA Goldman, Jan Magnus Bjordal, JK McGeachie, JM Bjordal, Jon Joensen, JR Basford, JS Chamberlain, KS Ramaswamy, Lucio Frigo, M Koenig, M Li, M Tullberg, Mark I. Johnson, Maurilio Sampaolesi, MM Schubert, O Ozcelik, P de Almeida, P de Almeida, Patrícia de Almeida, Paulo de Tarso Camillo de Carvalho, PC Silveira, R Albertini, R Albertini, RJ Fairclough, Rodrigo Álvaro Brandão Lopes-Martins, RT Chow, RT Chow, S Rao, S Rochkind, Shaiane Silva Tomazoni, T De Marchi, T Takema, TA Partridge, V Ricotti, W Lim, X Xu, Y Lampl, Y Moriyama, YY Huang   +60 more
core   +7 more sources

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]

, 2018
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi, Escudero Cuadrado, Luis María, Fernández Simón, Esther, Gallardo, Eduard, Gómez Gálvez, Pedro, Piñol Jurado, Patricia, Suárez Calvet, Xavier   +6 more
core   +1 more source

A Long-Term Study Evaluating the Effects of Nicorandil Treatment on Duchenne Muscular Dystrophy-Associated Cardiomyopathy in Mice

Journal of Cardiovascular Pharmacology and Therapeutics, 2022
Background: Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by dystrophin gene mutations affecting striated muscle. Due to advances in skeletal muscle treatment, cardiomyopathy has emerged as a leading cause of death.
Melanie Gartz PhD, MS, MHS, Margaret Haberman BS, Mariah J. Prom BS, Margaret J. Beatka BS, Jennifer L. Strande MD, PhD, Michael W. Lawlor MD, PhD   +5 more
doaj   +1 more source

Increased circulating levels of interleukin-6 induce perturbation in redox-regulated signaling cascades in muscle of dystrophic mice [PDF]

, 2017
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein.
Forcina, Laura, Musaro', Antonio, Nicoletti, Carmine, Pelosi, Laura, Scicchitano, Bianca Maria   +4 more
core   +3 more sources

Plantarflexion Contracture in the mdx Mouse [PDF]

American Journal of Physical Medicine & Rehabilitation, 2010
Contractures are a major clinical issue for patients with muscular dystrophies. However, it is unknown whether contractures are present in the widely used mdx mouse model of Duchenne muscular dystrophy. Therefore, the objectives of this study were to develop methods to measure muscle contractures in mice, to determine whether plantarflexion ...
Lisa L. Dorsey, Kristen A. Baltgalvis, Jarrod A. Call, Michael W. Garlich, Dawn A. Lowe   +4 more
openaire   +3 more sources