Results 61 to 70 of about 38,496 (259)
Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]
, 2014 Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph +1 more
core +1 more source
EMBO Molecular Medicine, 2013 HDAC inhibitors (HDACi) exert beneficial effects in mdx mice, by promoting endogenous regeneration; however, the cellular determinants of HDACi activity on dystrophic muscles have not been determined.
Chiara Mozzetta +11 more
doaj +1 more source
Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models. [PDF]
, 2019 Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Barthélémy, Florian +6 more
core +1 more source
Impact of Obesity on the Structured Histopathology of Chronic Rhinosinusitis Patients
The Laryngoscope, EarlyView.ABSTRACT Objectives Obesity is an established risk factor for asthma, which shares common inflammatory pathways with chronic rhinosinusitis (CRS). However, the link between obesity and CRS remains poorly understood. By identifying trends in the structured histopathology (SHP) of obese patients with CRS, we aim to better understand how changes in the ...
Daniel X. Ma +7 more
wiley +1 more source
Derived Koszul Duality and Involutions in the Algebraic K-Theory of Spaces
, 2010 We interpret different constructions of the algebraic $K$-theory of spaces as an instance of derived Koszul (or bar) duality and also as an instance of Morita equivalence. We relate the interplay between these two descriptions to the homotopy involution.
Blumberg, Andrew J., Mandell, Michael A.
core +1 more source
Lack of Dystrophin Affects Bronchial Epithelium in mdx Mice [PDF]
, 2016 Mild exercise training may positively affect the course of Duchenne Muscular Dystrophy (DMD). Training causes mild bronchial epithelial injury in both humans and mice, but no study assessed the effects of exercise in mdx mice, a well known model of DMD ...
BELLUARDO, Natale +8 more
core +1 more source
Impaired respiratory function in mdx and mdx/utrn+/− mice [PDF]
Muscle & Nerve, 2011 AbstractMuscle fibrosis is a prominent pathological feature that directly causes muscle dysfunction in Duchenne muscular dystrophy (DMD). The DMD mouse models, mdx mice and mdx mice with haploinsufficiency of the utrophin gene (mdx/utrn+/−), display progressive diaphragm fibrosis.
Ping, Huang +5 more
openaire +2 more sources
Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice [PDF]
, 2022 Tue L. Nielsen +5 more
openalex +1 more source
Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
PROTEOMICS, EarlyView.ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source
Química Nova, 2014 Polygala cyparissias is a plant widespread in Southern Latin America. Recently, we demonstrated the gastroprotective activity of the extract, as well as for one of the isolated metabolites-1,7-dihydroxy-2,3-methylenedioxyxanthone (MDX).
Luiz Carlos Klein-Júnior +3 more
doaj +1 more source