Results 111 to 120 of about 1,087,549 (254)

Brain glucose metabolism as a neuronal substrate of the abnormal behavioral response to stress in the mdx mouse, a model of Duchenne muscular dystrophy

Neurobiology of Disease
Duchenne muscular dystrophy (DMD) is associated with a range of cognitive and behavioral problems. Brain-related comorbidities show clinical heterogeneity depending on the position of the mutation within the multi-promoter dystrophin (DMD) gene, likely ...
Sébastien Goutal, Marion Lancien, François Rivier, Nicolas Tournier, Cyrille Vaillend   +4 more
doaj   +1 more source

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

Neurobiology of Disease, 2008
This review discusses various issues to consider when developing standard operating procedures for pre-clinical studies in the mdx mouse model of Duchenne muscular dystrophy (DMD).
Miranda D. Grounds, Hannah G. Radley, Gordon S. Lynch, Kanneboyina Nagaraju, Annamaria De Luca   +4 more
doaj   +1 more source

Evidence of oxidative stress in mdx mouse muscle: Studies of the pre-necrotic state [PDF]

, 1998
Marie‐Hélène Disatnik, Jyotsna Dhawan, Yip Yu, M. Flint Beal, Michelle Whirl‐Carrillo, Alexa A. Franco, Thomas A. Rando   +6 more
openalex   +1 more source

Galectin-1 Protein Therapy Prevents Pathology and Improves Muscle Function in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Molecular Therapy, 2015
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex.
Pam M Van Ry, R. Wuebbles, Megan Key, D. Burkin   +3 more
semanticscholar   +1 more source

Histological Study of Masseter Muscle in a Mouse Muscular Dystrophy Model (mdx mouse).

The Bulletin of Tokyo Dental College, 2000
Histological changes in the masseter muscle were observed over time in mdx mice, a muscular dystrophy model. It was found that marked necrosis occurs about the time of weaning at around 4 weeks of age; then the tissue actively regenerates at 8 weeks and stabilizes as regenerated muscle with centronuclei at 15 weeks old.
Makito Amano, Hiroki Watanabe, Shinichi Abe, Norio Kasahara, Masatoshi Yoshii, Yoshinobu Ide   +5 more
openaire   +4 more sources

Herpes simplex virus vector-mediated dystrophin gene transfer and expression in MDX mouse skeletal muscle [PDF]

, 1999
Giridhar R. Akkaraju, Johnny Huard, Eric P. Hoffman, William F. Goins, Ryan Pruchnic, Simon C. Watkins, Justus B. Cohen, Joseph C. Glorioso   +7 more
openalex   +1 more source

Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers

Molecules, 2015
The primary deficiency in the membrane cytoskeletal protein dystrophin results in complex changes in dystrophic muscles. In order to compare the degree of secondary alterations in differently affected subtypes of skeletal muscles, we have conducted a ...
A. Holland, M. Henry, P. Meleady, Claudia K. Winkler, Mirjam Krautwald, H. Brinkmeier, K. Ohlendieck   +6 more
semanticscholar   +1 more source

PKC theta ablation improves healing in a mouse model of muscular dystrophy.

PLoS ONE, 2012
Inflammation is a key pathological characteristic of dystrophic muscle lesion formation, limiting muscle regeneration and resulting in fibrotic and fatty tissue replacement of muscle, which exacerbates the wasting process in dystrophic muscles.
Luca Madaro, Andrea Pelle, Carmine Nicoletti, Annunziata Crupi, Valeria Marrocco, Gianluca Bossi, Silvia Soddu, Marina Bouché   +7 more
doaj   +1 more source

Selective Reduction in the Nicotinic Acetylcholine Receptor and Dystroglycan at the Postsynaptic Apparatus ofmdxMouse Superior Cervical Ganglion [PDF]

, 2000
Maria Letizia Zaccaria, Maria Egle De Stefano, Cecilia Gotti, Tamara C. Petrucci, Paola Paggi   +4 more
openalex   +1 more source

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy

Cell Death and Disease
Absence of dystrophin protein causes cardiac dysfunction in patients with Duchenne muscular dystrophy (DMD). Unlike boys with DMD, the common mouse model of DMD (B10-mdx) does not manifest cardiac deficits until late adulthood.
James S. Novak, Amy Lischin, Prech Uapinyoying, Ravi Hindupur, Young Jae Moon, Surajit Bhattacharya, Sarah Tiufekchiev-Grieco, Victoria Barone, Davi A. G. Mázala, Iteoluwakishi H. Gamu, Gabriela Walters, Jyoti K. Jaiswal   +11 more
doaj   +1 more source