Results 211 to 220 of about 1,087,549 (254)
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Passive avoidance behaviour deficit in the mdx mouse
Neuromuscular Disorders, 1991Thirty per cent of boys with Duchenne muscular dystrophy (DMD) suffer from various degrees of mental retardation. Since dystrophin, the protein absent in muscles of boys with DMD, is produced also in the brain, it was postulated that the deficiency of brain dystrophin might account for the mental retardation found in DMD boys.
Muntoni F., Mateddu A., SERRA, Gino
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Postnatal changes in sarcolemmal organization in the mdx mouse
Neuromuscular Disorders, 2005The tibialis anterior muscles of mdx mice degenerate between 3 and 4 weeks after birth and then partially recover. We show that the membrane cytoskeleton at the mdx sarcolemma is disorganized at 18-days postnatal, and becomes more disorganized at 4 weeks compared to earlier or later times.
Patrick Reed, Robert J. Bloch
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Axonal transport in mdx mouse sciatic nerve
Journal of the Neurological Sciences, 1989Anterograde and retrograde flows of acetylcholinesterase (AChE) in sciatic nerves of adult mdx mice were compared with those of normal mice. Specific molecular forms of AChE were resolved by high-performance liquid chromatography such that slow anterograde (G1 + G2), fast anterograde and fast retrograde (G4 and A12) flows could be simultaneously ...
Etsuo Chihara +6 more
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Prostaglandin metabolism in dystrophin-deficient MDX mouse muscle [PDF]
Biochemical Society Transactions, 1991 An accumulation of intracellular calcium has been implicated in the processes of damage to dystrophic muscle (1-31. Previous studies have also indicated calcium-induced damage to normal skeletal muscle in associated with a release of prostaglandins EZ and F2a [4] and that inhibition of phospholipase enzymes reduces some of the features of muscle damage
Anne McArdle +3 more
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ELECTROMYOGRAPHIC AND NERVE CONDUCTION STUDIES IN THE mdx MOUSE
American Journal of Physical Medicine & Rehabilitation, 1992Electromyographic responses to needle-electrode insertion and repetitive indirect stimulation were recorded from gastrocnemius, soleus and cranial tibialis muscles of normal and dystrophic (mdx) mice at 20-154 days. Recordings from myotonic (ADRmto) mice served as controls for "true" myotonia.
Richard K. Entrikin +2 more
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Functional regeneration in the hindlimb skeletal muscle of the mdx mouse [PDF]
Journal of Muscle Research and Cell Motility, 1988 The pattern of spontaneous skeletal muscle degeneration and clinical recovery hindlimb muscles of the mdx mutant mouse was examined for functional and metabolic confirmation of apparent structural regeneration. The contractile properties, histochemical staining and myosin light chain and parvalbumin contents of extensor digitorum longus (EDL) and ...
Judy E. Anderson +2 more
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Molecular forms of acetylcholinesterase in dystrophic (mdx) mouse tissues
Neuromuscular Disorders, 1992We analyzed the activity of acetylcholinesterase (AChE) and its molecular forms in the tissues of normal and dystrophic (mdx) mice, at different developmental stages. We studied the brain, the heart and the serum, in addition to four predominantly fast-twitch muscles (tibialis, plantaris, gastrocnemius and extensor digitorum longus (EDL)) and the slow ...
Oliver, Lisa +4 more
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A noninvasive procedure to detect muscle weakness in the mdx mouse
Muscle & Nerve, 1990AbstractThe forward pulling tension exerted by individual mice was measured nearly isometrically in a simple apparatus designed to determine whole body tension (WBT). WBT determinations on control (C57BI10/SnJ) and experimental (C57BI10‐mdx) mice indicate muscle weakness which lasts throughoout the lifespan of mdx mice.
R. V. Makiejus, C. G. Carlson
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Oxyradical Damage and Mitochondrial Enzyme Activities in the mdx Mouse
Neuropediatrics, 1995A number of studies have already been undertaken to investigate involvement of oxyradicals in muscle diseases by means of measurements of oxyradical protective enzymes. We investigated o-tyrosine, which is a biomarker for OH radical damage in vivo, in 10 mdx and 10 control mice. We also measured mitochondrial enzymes in muscle homogenates of 10 mdx and
Gert Lubec +5 more
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Pre-clinical screening of drugs using the mdx mouse
Neuromuscular Disorders, 2000The genetically dystrophin-deficient mdx mouse, with its characteristic and regular exercise-induced loss of strength, is a useful experimental platform on which to screen potential drug therapies in the treatment of some dystrophic diseases. Pharmacological agents of several chemical and functional classes were examined in their ability to reduce the ...
Michael S. Hudecki +2 more
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