Results 191 to 200 of about 18,188 (219)
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Assessing functional performance in the mdx mouse model.
Journal of visualized experiments : JoVE, 2014Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder for which no cure is available. Nevertheless, several potential pharmaceutical compounds and gene therapy approaches have progressed into clinical trials. With improvement in muscle function being the most important end point in these trials, a lot of emphasis has ...
Aartsma-Rus, A., Putten, M. van
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Oxyradical Damage and Mitochondrial Enzyme Activities in the mdx Mouse
Neuropediatrics, 1995A number of studies have already been undertaken to investigate involvement of oxyradicals in muscle diseases by means of measurements of oxyradical protective enzymes. We investigated o-tyrosine, which is a biomarker for OH radical damage in vivo, in 10 mdx and 10 control mice. We also measured mitochondrial enzymes in muscle homogenates of 10 mdx and
E, Hauser +5 more
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Force and stiffness of old dystrophic (mdx) mouse skeletal muscles
Muscle & Nerve, 1998It has recently been suggested, based on studies of tissue pathology, that the limb muscles of old mdx mice may be a good model for the muscular changes seen in human Duchenne muscular dystrophy. To test this hypothesis, we measured force and stiffness of soleus and extensor digitorum longus (EDL) muscles of old (20-21 months) mdx mice and age-matched ...
J, Bobet, R F, Mooney, T, Gordon
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Radiation inhibition of mdx mouse muscle regeneration: Dose and age factors
Muscle & Nerve, 1995AbstractA single hind limb was irradiated with 12, 18, 24, or 30 Gy in mdx and C57 mice aged 12, 21, or 42 days to determine regeneration inhibition dose‐response curves in different aged dystrophic mice and to characterize radiation side‐effects in normal mice.
J G, Quinlan +5 more
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Therapeutic screening in the mdx mouse
Neuromuscular Disorders, 2000CONTE, Diana, DE LUCA, Annamaria
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DNA concentrations are increased in MDX mouse muscles
Biochemical Society Transactions, 1991P A, MacLennan +2 more
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Serum and organ indices of the mdx dystrophic mouse.
Research communications in chemical pathology and pharmacology, 1992Duchenne muscular dystrophy (DMD) is a fatal disease for which there is no effective treatment. The cause of death in patients with DMD is often cardiovascular and pulmonary dysfunction. This clinical observation, combined with experimental findings, suggests that other non-muscle organ systems may be affected in the dystrophic disease state.
G A, Brazeau, M, Mathew, R K, Entrikin
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The cardiomyopathy in the mdx mouse
Journal of Molecular and Cellular Cardiology, 1988openaire +1 more source
Is cognitive impairment progressive in the mdx mouse?
Neuromuscular Disorders, 2017E. Bagdatlioglu +5 more
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