Results 181 to 190 of about 18,188 (219)

Prostaglandin metabolism in dystrophin-deficient MDX mouse muscle

Biochemical Society Transactions, 1991
An accumulation of intracellular calcium has been implicated in the processes of damage to dystrophic muscle (1-31. Previous studies have also indicated calcium-induced damage to normal skeletal muscle in associated with a release of prostaglandins EZ and F2a [4] and that inhibition of phospholipase enzymes reduces some of the features of muscle damage
A, McArdle, A, Foxley, R H, Edwards, M J, Jackson   +3 more
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Passive avoidance behaviour deficit in the mdx mouse

Neuromuscular Disorders, 1991
Thirty per cent of boys with Duchenne muscular dystrophy (DMD) suffer from various degrees of mental retardation. Since dystrophin, the protein absent in muscles of boys with DMD, is produced also in the brain, it was postulated that the deficiency of brain dystrophin might account for the mental retardation found in DMD boys.
Muntoni F., Mateddu A., SERRA, Gino
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P.1.18 NMR imaging comparison of dystrophic mouse models: mdx, Large, mdx/Large

Neuromuscular Disorders, 2013
The mdx is the mouse model for Duchenne muscular dystrophy (MD), but with a benign phenotype. The large-myd mouse (Lg) has a mutation in the glycosyltransferase like Large gene and models the Congenital MD 1D, with a severe phenotype. The double mutant mdx/Lg, developed in our lab (1), has a more severe phenotype than both parental lineages. Dystrophic
A.B. Martins-Bach, J. Malheiros, P.C. Melo Machado, C.F. Almeida, B. Matot, P.L. de Sousa, A. Tannús, P.G. Carlier, M. Vainzof   +8 more
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Postnatal changes in sarcolemmal organization in the mdx mouse

Neuromuscular Disorders, 2005
The tibialis anterior muscles of mdx mice degenerate between 3 and 4 weeks after birth and then partially recover. We show that the membrane cytoskeleton at the mdx sarcolemma is disorganized at 18-days postnatal, and becomes more disorganized at 4 weeks compared to earlier or later times.
Patrick, Reed, Robert J, Bloch
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Pre-clinical screening of drugs using the mdx mouse

Neuromuscular Disorders, 2000
The genetically dystrophin-deficient mdx mouse, with its characteristic and regular exercise-induced loss of strength, is a useful experimental platform on which to screen potential drug therapies in the treatment of some dystrophic diseases. Pharmacological agents of several chemical and functional classes were examined in their ability to reduce the ...
J A, Granchelli, C, Pollina, M S, Hudecki   +2 more
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ELECTROMYOGRAPHIC AND NERVE CONDUCTION STUDIES IN THE mdx MOUSE

American Journal of Physical Medicine & Rehabilitation, 1992
Electromyographic responses to needle-electrode insertion and repetitive indirect stimulation were recorded from gastrocnemius, soleus and cranial tibialis muscles of normal and dystrophic (mdx) mice at 20-154 days. Recordings from myotonic (ADRmto) mice served as controls for "true" myotonia.
G T, Carter, K J, Longley, R K, Entrikin
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Molecular forms of acetylcholinesterase in dystrophic (mdx) mouse tissues

Neuromuscular Disorders, 1992
We analyzed the activity of acetylcholinesterase (AChE) and its molecular forms in the tissues of normal and dystrophic (mdx) mice, at different developmental stages. We studied the brain, the heart and the serum, in addition to four predominantly fast-twitch muscles (tibialis, plantaris, gastrocnemius and extensor digitorum longus (EDL)) and the slow ...
Oliver, Lisa, Chatel, Jean-Marc, Massoulié, Jean, Vigny, Marc, Vallette, François   +4 more
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THE mdx MOUSE SKELETAL MUSCLE MYOPATHY: II. CONTRACTILE PROPERTIES

Neuropathology and Applied Neurobiology, 1988
The mdx mouse skeletal muscle myopathy: II. Contractile propertiesThe contractile properties of soleus muscles from mdx and control mice aged between 26 and 350 days were compared with those of muscles from similarly aged control mice. Mdx mice were in general heavier (their individual soleus muscles were also heavier), of greater cross–sectional area ...
G R, Coulton, N A, Curtin, J E, Morgan, T A, Partridge   +3 more
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Normal Cochlear Function in mdx and mdx^Cv3 Duchenne Muscular Dystrophy Mouse Models

The Laryngoscope, 1999
AbstractObjectives/Hypothesis: Sensorineural hearing loss has been found in association with inherited muscular dystrophies in humans and in mouse models. An increased brainstem auditory evoked response threshold has been previously reported in the dystrophin‐deficient mdx mouse model for Duchenne muscular dystrophy, suggesting that full‐length ...
D A, Pillers, N M, Duncan, S J, Dwinnell, S M, Rash, J B, Kempton, D R, Trune   +5 more
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Regeneratedmdxmouse skeletal muscle shows differential mRNA expression

Journal of Applied Physiology, 2002
Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-old mouse mdx muscle at a time when the skeletal ...
B S, Tseng, P, Zhao, J S, Pattison, S E, Gordon, J A, Granchelli, R W, Madsen, L C, Folk, E P, Hoffman, F W, Booth   +8 more
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