Results 51 to 60 of about 1,892,513 (283)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

COMPARISON OF MISSING VALUE IMPUTATION USING MEAN, BAYESIAN KNN, AND NON-BAYESIAN KNN ON TEP GENE EXPRESSION DATA

open access: yesMedia Statistika
Analysis of gene expression data, particularly in cancer data, often faces challenges due to the presence of missing values. One approach to overcome this is data imputation.
Mastika Mastika   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Signal Estimation with Additive Error Metrics in Compressed Sensing [PDF]

open access: yes, 2013
Compressed sensing typically deals with the estimation of a system input from its noise-corrupted linear measurements, where the number of measurements is smaller than the number of input components.
Danielle Carmon   +4 more
core   +3 more sources

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Spectral Index of the Diffuse Radio Background Measured From 100 to 200 MHz [PDF]

open access: yes, 2008
The mean absolute brightness temperature of the diffuse radio background was measured as a function of frequency in a continuous band between 100 and 200 MHz over an effective solid angle of ~pi str at high Galactic latitude.
Alan E. E. Rogers   +16 more
core   +2 more sources

Minimum Mean Absolute Error Predictors for Lossless Image Coding

open access: yesIEICE Transactions on Information and Systems, 2008
In this paper, we investigate minimum mean absolute error (mmae) predictors for lossless image coding. In some prediction-based lossless image coding systems, coding performance depends largely on the efficiency of predictors. In this case, minimum mean square error (mmse) predictors are often used.
Yoshihiko Hashidume   +2 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Multi-Objective Transport System Based on Regression Analysis and Genetic Algorithm Using Transport Data

open access: yesIEEE Access, 2019
Intelligent transportation system (ITS) is a cutting-edge traffic solution employing state-of-the-art information and communication technologies. Optimized bus-scheduling, being an integral part of ITS, ensures safety, efficiency, traffic congestion ...
Moubeen Farooq Khan   +3 more
doaj   +1 more source

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