Results 41 to 50 of about 1,404,374 (329)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

On Mean Field Convergence and Stationary Regime [PDF]

, 2011
Assume that a family of stochastic processes on some Polish space $E$ converges to a deterministic process; the convergence is in distribution (hence in probability) at every fixed point in time.
Benaim, Michel, Boudec, Jean-Yves Le
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

On the convergence of sequences in ℝ+ through weighted geometric means via multiplicative calculus and application to intuitionistic fuzzy numbers

Journal of Taibah University for Science, 2022
We define weighted geometric mean method of convergence for sequences in [Formula: see text] by using multiplicative calculus and obtain necessary and sufficient conditions under which convergence of sequences in [Formula: see text] follows from ...
Enes Yavuz
doaj   +1 more source

Currents and Flat Chains Associated to Varifolds, with an Application to Mean Curvature Flow

, 2008
We prove under suitable hypotheses that convergence of integral varifolds implies convergence of associated mod 2 flat chains and subsequential convergence of associated integer-multiplicity rectifiable currents.
White, Brian
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Strong Convergence of Cesàro Mean Iterations for Nonexpansive Nonself-Mappings in Banach Spaces

Fixed Point Theory and Applications, 2007
Let E be a real uniformly convex Banach space which admits a weakly sequentially continuous duality mapping from E to E*, C a nonempty closed convex subset of E which is also a sunny nonexpansive retract of E, and T:C→E a non-expansive nonself ...
Rabian Wangkeeree
doaj   +1 more source

ON DOUBLE WEIGHTED MEAN STATISTICAL CONVERGENCE

International Journal of Research -GRANTHAALAYAH, 2017
In this paper, we have established some new theorems on double weighted mean statistical convergence of double sequences, which gives some new results and generalizes the some previous known results of Karakaya.
Raghuvanshi, Aditya Kumar, B.K. Singh, Ripendra Kumar   +2 more
openaire   +2 more sources