Results 121 to 130 of about 5,400,024 (317)
A REMARK ON A CLOSED ORIENTABLE HYPERSURFACE WITH CONSTANT REDUCED MEAN CURVATURE [PDF]
, 1968 Yoshihiko Tazawa
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Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
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On a Piece of Hypersurface in a Riemannian Manifold with Mean Curvature Bounded away from Zero [PDF]
, 1967 Yoshie Katsurada
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
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Submanifolds with parallel mean curvature vector [PDF]
, 1971 Kentarô Yano, Shigeru Ishihara
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Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
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Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
An algorithm for Mean Curvature Motion
Interfaces and Free Boundaries, Mathematical Analysis, Computation and Applications, 2004 We propose in this paper a new algorithm for computing the evolution by mean curvature of a hypersurface. Our algorithm is a variant of the variational approach of Almgren, Taylor and Wang [2]. We show that it approximates, as the time-step goes to zero, the generalized motion(in the sense of barriers or viscosity solutions). The results still hold for
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Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
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On an inequality of mean curvatures of higher degree [PDF]
, 1971 Bang‐Yen Chen
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