Results 101 to 110 of about 528,992 (279)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature. [PDF]

J Refract Surg, 2022
Pavlatos E, Chen S, Chamberlain W, Huang D, Li Y.   +4 more
europepmc   +1 more source

Constant mean curvature foliation: singularity structure and curvature estimate [PDF]

Pacific Journal of Mathematics, 1996
The author studies codimension-one foliations of 3-dimensional Riemannian manifolds with leaves of constant mean curvature that can vary from leaf to leaf. The foliations are allowed to have isolated center singularities, that is, points having deleted neighborhoods which are foliated by compact leaves.
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Surfaces of Revolution with Constant Mean Curvature in Galilean 3-Space

Mathematics
Revolution surfaces with zero mean curvature in the Galilean 3-space have been extensively studied in the literature. However, revolution surfaces with non-zero constant mean curvature in this geometric setting have not yet been investigated in a ...
İsmet Gölgeleyen, Yusuf Yaylı, Elif Yaren Bulgan   +2 more
doaj   +1 more source

On Concircular Transformations in Finsler Spaces

پژوهش‌های ریاضی, 2021
Randers metrics are the most important class of Finsler metrics which is defined by a Riemannian metric  and a 1-form  as    . In this paper, the concept of geodesic circle preserve transformations in  Finslerian space is studied and the weak Einstein ...
Samaneh Sadat Saberali, Bahman Rezaei
doaj  

Local Well-Posedness of Skew Mean Curvature Flow for Small Data in d ≥ 4 Dimensions. [PDF]

Commun Math Phys, 2022
Huang J, Tataru D.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Improved Detection of Chronic Obstructive Pulmonary Disease at Chest CT Using the Mean Curvature of Isophotes. [PDF]

Radiol Artif Intell, 2022
Savadjiev P, Gallix B, Rezanejad M, Bhatnagar S, Semionov A, Siddiqi K, Forghani R, Reinhold C, Eidelman DH, Dandurand RJ.   +9 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source