Results 81 to 90 of about 4,058,790 (257)
Mean curvature flow singularities for mean convex surfaces [PDF]
, 1999 We study the evolution by mean curvature of a smooth n–dimensional surfaceM Rn+1, compact and with positive mean curvature. We first prove an estimate on the negative part of the scalar curvature of the surface.
Huisken, G., Sinestrari, C.
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mean Curvature of Riemannian Foliations
, 1996 It is shown that a suitable conformai change of the metric in the leaf direction of a transversally oriented Riemannian foliation on a closed manifold will make the basic component of the mean curvature harmonic.
Ernst A. Ruh, Peter March, Maung Min-Oo
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Constant mean curvature surfaces [PDF]
, 2016 In this article we survey recent developments in the theory of constant mean cur- vature surfaces in homogeneous 3-manifolds, as well as some related aspects on ex- istence and descriptive results for H -laminations and CMC foliations of Riemannian n ...
Tinaglia, Giuseppe; id_orcid +2 more
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Totally real surfaces in CP2 with parallel mean curvature vector
International Journal of Mathematics and Mathematical Sciences, 1992 It has been shown that a totally real surface in CP2 with parallel mean curvature vector and constant Gaussian curvature is either flat or totally geodesic.
M. A. Al-Gwaiz, Sharief Deshmukh
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Diameter, Area, and Mean curvature [PDF]
In this note, we extend diameter bounds of Simon, Topping, and Wu--Zheng to submanifolds with boundary and (potentially non-compact) ambient manifolds with minor curvature restrictions. The bound is dependent on both an integral of mean curvature and the
Marx-Kuo, Jared, Chambers, Gregory R.
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source