Results 71 to 80 of about 4,058,790 (257)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Convergence rate of the weighted conformal mean curvature flow
Analysis and Geometry in Metric SpacesIn this article, we study the convergence rate of the following Yamabe-type flow Rϕ(t)m=0inMand∂∂tg(t)=2(hϕ(t)m−Hϕ(t)m)g(t)∂∂tϕ(t)=m(Hϕ(t)m−hϕ(t)m)on∂M{R}_{\phi \left(t)}^{m}=0\hspace{0.33em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}M\hspace ...
Hamanaka Shota, Tung Ho Pak
doaj +1 more source
Ground state solutions for the Hénon prescribed mean curvature equation
Advances in Nonlinear Analysis, 2018 In this paper, we consider the analogous of the Hénon equation for the prescribed mean curvature problem in ℝN{{\mathbb{R}^{N}}}, both in the Euclidean and in the Minkowski spaces. Motivated by the studies of Ni and Serrin [W. M. Ni and J.
Azzollini Antonio
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Phon Mean oral history recording
, 2001 An audio recording of an oral history of Phon Mean about fleeing Cambodia with her family at age ten and coming to the United States. She talks about life in Cambodia when she was a child and then about life in the U.S., including school, her first job ...
Mean, Phon
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Rotational Hypersurfaces in S3(r)R Product Space
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2017 We consider rotational hypersurfaces in S3(r) R product space of five dimensional Euclidean space E5. We calculate the mean curvature and the Gaussian curvature, and give some results.
Erhan Güler, Ömer Kişi
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source