Results 71 to 80 of about 119,664 (268)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Singular surfaces of revolution with prescribed unbounded mean curvature
Anais da Academia Brasileira de Ciências: We give an explicit formula for singular surfaces of revolution with prescribed unbounded mean curvature. Using this mean curvature, we give conditions for certain types of singularities of those surfaces. Periodicity of that surface is also discussed.
MARTINS LUCIANA F. +3 more
doaj +1 more source
Mean curvature blow up in mean curvature flow
, 2009 In this note we establish that finite-time singularities of the mean curvature flow of compact Riemannian submanifolds are characterised by the blow up of the mean curvature.
openaire +2 more sources
The mean curvature at the first singular time of the mean curvature flow
Annales de l'Institut Henri Poincaré C, Analyse non linéaire, 2010 Consider a family of smooth immersions F( \cdot ,t):M^{n}\rightarrow \mathbb{R}^{n + 1} of closed hypersurfaces in \mathbb{R}^{n + 1} moving by the mean curvature flow \frac{\partial F(p,t)}{\partial t} = −
Le, Nam Q., Sesum, Natasa
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Convergence rate of the weighted conformal mean curvature flow
Analysis and Geometry in Metric SpacesIn this article, we study the convergence rate of the following Yamabe-type flow Rϕ(t)m=0inMand∂∂tg(t)=2(hϕ(t)m−Hϕ(t)m)g(t)∂∂tϕ(t)=m(Hϕ(t)m−hϕ(t)m)on∂M{R}_{\phi \left(t)}^{m}=0\hspace{0.33em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}M\hspace ...
Hamanaka Shota, Tung Ho Pak
doaj +1 more source
Molecular Surface Estimation by Geometric Coupled Distance Functions
IEEE Access, 2020 Estimating the surface from given atoms with location and size information is a fundamental task in many fields, such as molecular dynamics and protein analysis. In this paper, we present a novel method for such surface estimation. Our method is based on
Yuanhao Gong, Yong Chen
doaj +1 more source
Precision measurement of the mean curvature
Physical Review D, 2006 7 pages accepted for publication in PRD. Final published version with more on how the curvature constraints depend on the technique used for measuring ...
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source