Results 161 to 170 of about 5,121,571 (362)

An Application of Symbolic Methods to the Treatment of Mean Curvatures in Hyperspace [PDF]

, 1911
William Hunt Bates
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Differentiating Between Contact Lens Warpage and Keratoconus Using OCT Maps of Corneal Mean Curvature and Epithelial Thickness. [PDF]

J Refract Surg, 2022
Pavlatos E, Harkness B, Louie D, Chamberlain W, Huang D, Li Y.   +5 more
europepmc   +1 more source

Rotational Hypersurfaces in S3(r)R Product Space

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2017
We consider rotational hypersurfaces in S3(r) R product space of five dimensional Euclidean space E5. We calculate the mean curvature and the Gaussian curvature, and give some results.
Erhan Güler, Ömer Kişi
doaj   +1 more source

Three theorems on manifolds with bounded mean curvature [PDF]

, 1965
F. J. Almgren
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

An existence theorem for surfaces of constant mean curvature [PDF]

, 1969
Henry C. Wente
openalex   +1 more source

Noncollapsing in mean-convex mean curvature flow [PDF]

Geometry & Topology, 2012
We provide a direct proof of a non-collapsing estimate for compact hypersurfaces with positive mean curvature moving under the mean curvature flow: Precisely, if every point on the initial hypersurface admits an interior sphere with radius inversely proportional to the mean curvature at that point, then this remains true for all positive times in the ...
openaire   +4 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

On Concircular Transformations in Finsler Spaces

پژوهش‌های ریاضی, 2021
Randers metrics are the most important class of Finsler metrics which is defined by a Riemannian metric  and a 1-form  as    . In this paper, the concept of geodesic circle preserve transformations in  Finslerian space is studied and the weak Einstein ...
Samaneh Sadat Saberali, Bahman Rezaei
doaj