Results 181 to 190 of about 329,911 (321)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Ground states for the prescribed mean curvature equation [PDF]

, 1987
L. A. Peletier, James Serrin
openalex   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Mean curvature functions for codimension-one foliations with all leaves compact [PDF]

, 1984
Paweł Walczak
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Singularity of mean curvature flow with bounded mean curvature and Morse index [PDF]

arXiv
We study the multiplicity of the singularity of mean curvature flow with bounded mean curvature and Morse index. For $3\leq n\leq 6$, we show that either the mean curvature or the Morse index blows up at the first singular time for a closed smooth embedded mean curvature flow in $\mathbb{R}^{n+1}$.
arxiv  

The diameter of an immersed Riemannian manifold with bounded mean curvature [PDF]

, 1981
Th. Koufogiorgos, Ch. Baikoussis
openalex   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Generalized Harnack Inequality for Mean Curvature Flow and Ancient Solutions [PDF]

arXiv
The goal of this paper is to relax convexity assumption on some classical results in mean curvature flow. In the first half of the paper, we prove a generalized version of Hamilton's differential Harnack inequality which holds for mean convex solutions to mean curvature flow with a lower bound on $\frac{\lambda_1}{H}$ where $\lambda_1$ is the smallest ...
arxiv  

Mean curvature for certain $\textit{p}$-planes in Sasakian manifolds [PDF]

, 1982
Shigeyoshi Fujimura
openalex   +1 more source