Results 51 to 60 of about 5,400,024 (317)
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Mean curvature flow with surgery [PDF]
Duke Mathematical Journal, 2017 We give a new proof for the existence of mean curvature flow with surgery of 2-convex hypersurfaces in $R^N$, as announced in arXiv:1304.0926. Our proof works for all $N \geq 3$, including mean convex surfaces in $R^3$. We also derive a priori estimates for a more general class of flows in a local and flexible setting.
Haslhofer, Robert, Kleiner, Bruce
openaire +5 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
A general halfspace theorem for constant mean curvature surfaces
, 2011 In this paper, we prove a general halfspace theorem for constant mean curvature surfaces. Under certain hypotheses, we prove that, in an ambient space M^3, any constant mean curvature H_0 surface on one side of a constant mean curvature H_0 surface ...
Mazet, Laurent
core +4 more sources
Graphs with Parallel Mean Curvature [PDF]
Proceedings of the American Mathematical Society, 1989 We prove that if the graph Γ f = { ( x , f ( x ) ) :
openaire +2 more sources
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Mean curvature flow in a Ricci flow background
, 2012 Following work of Ecker, we consider a weighted Gibbons-Hawking-York functional on a Riemannian manifold-with-boundary. We compute its variational properties and its time derivative under Perelman's modified Ricci flow.
B. Kleiner +14 more
core +1 more source
Immersions of bounded mean curvature
Archiv der Mathematik, 1979 Archiv Der ...
Hasanis, T., Koutroufiotis, D.
openaire +3 more sources
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Mean curvature flows and isotopy problems [PDF]
, 2012 In this note, we discuss the mean curvature flow of graphs of maps between Riemannian manifolds. Special emphasis will be placed on estimates of the flow as a non-linear parabolic system of differential equations.
Wang, Mu-Tao
core