Results 51 to 60 of about 117,814 (315)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Characterizations of Unit Darboux Ruled Surface with Quaternions

open access: yesJournal of New Theory, 2023
This paper presents a quaternionic approach to generating and characterizing the ruled surface drawn by the unit Darboux vector. The study derives the Darboux frame of the surface and relates it to the Frenet frame of the base curve. Moreover, it obtains
Abdussamet Çalışkan
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Constant mean curvature surfaces with circular boundary in R³

open access: yesAnais da Academia Brasileira de Ciências, 2006
In this work we deal with surfaces immersed in R³ with constant mean curvature and circular boundary. We improve some global estimates for area and volume of such immersions obtained by other authors.
Pedro A. Hinojosa
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Graphs with Parallel Mean Curvature [PDF]

open access: yesProceedings of the American Mathematical Society, 1989
We prove that if the graph Γ f = { ( x , f ( x ) ) :
openaire   +1 more source

Mean Curvature Flow of Mean Convex Hypersurfaces [PDF]

open access: yesCommunications on Pure and Applied Mathematics, 2016
In the last 15 years, White and Huisken‐Sinestrari developed a far‐reaching structure theory for the mean curvature flow of mean convex hypersurfaces. Their papers provide a package of estimates and structural results that yield a precise description of singularities and of high‐curvature regions in a mean convex flow.In the present paper, we give a ...
Haslhofer, Robert, Kleiner, Bruce
openaire   +2 more sources

MCnet: A Neural Network Method for Mean Curvature Optimization on Image Surfaces

open access: yesIEEE Access
Mean curvature is fundamentally important for various research fields, including differential geometry in mathematics, cell membrane modeling in biophysics and image processing in computer vision.
Zhili Wei, Wenming Tang, Yuanhao Gong
doaj   +1 more source

Constant Mean Curvature Spacelike Surfaces in Lorentzian Warped Products

open access: yesAdvances in Mathematical Physics, 2015
We characterize the spacelike slices of a Lorentzian warped product as the only constant mean curvature spacelike surfaces under suitable geometrical and physical assumptions.
Juan A. Aledo, Rafael M. Rubio
doaj   +1 more source

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