Results 121 to 130 of about 872,045 (323)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

A remark on gradient estimates for spacelike mean curvature flow with boundary conditions [PDF]

open access: yesarXiv, 2016
We prove a gradient estimate for graphical spacelike mean curvature flow with a general Neumann boundary condition in dimension $n=2$. This then implies that the mean curvature flow exists for all time and converges to a translating solution.
arxiv  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

CFD-based investigation of turbulent flow behavior in 90-deg pipe bends

open access: yesJournal of Applied Research in Technology & Engineering
This work investigated the influence of bend curvature on the parameters of turbulent flow through a 90° pipe bend using the numerical CFD method, implemented in ANSYS Fluent. The numerical predictions were validated to be in good agreement with existing
Rilwan Kayode Apalowo   +1 more
doaj   +1 more source

The Mean Curvature Flow in Minkowski Spaces [PDF]

open access: yesarXiv, 2017
Studying the geometric flow plays a powerful role in mathematics and physics. In this paper, we introduce the mean curvature flow on Finsler manifolds and give a number of examples of the mean curvature flow. For Minkowski spaces, a special case of Finsler manifolds, we will prove the existence and uniqueness for solution of the mean curvature flow and
arxiv  

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Eventual Regularization of Fractional Mean Curvature Flow [PDF]

open access: yesarXiv, 2019
We show that any open set that is a finite distance away from a Lipschitz subgraph will become a Lipschitz subgraph after flowing under fractional mean curvature flow for a finite, universal time. Our proof is quantitative and inherently nonlocal, as the corresponding statement is false for classical mean curvature flow.
arxiv  

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