Results 121 to 130 of about 6,607,246 (296)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
CFD-based investigation of turbulent flow behavior in 90-deg pipe bends
Journal of Applied Research in Technology & EngineeringThis work investigated the influence of bend curvature on the parameters of turbulent flow through a 90° pipe bend using the numerical CFD method, implemented in ANSYS Fluent. The numerical predictions were validated to be in good agreement with existing
Rilwan Kayode Apalowo +1 more
doaj +1 more source
Noncollapsing in mean-convex mean curvature flow [PDF]
Geometry & Topology, 2012 We provide a direct proof of a non-collapsing estimate for compact hypersurfaces with positive mean curvature moving under the mean curvature flow: Precisely, if every point on the initial hypersurface admits an interior sphere with radius inversely proportional to the mean curvature at that point, then this remains true for all positive times in the ...
openaire +5 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
A CFD Description of the Breach Flow of an Overtopped Embankment Dam
InfrastructuresWe investigate the flow over a breached dam through combined measurements and numerical simulations, revealing key topological features of the mean flow, including separation and stagnation surfaces, attached vortices, secondary currents, and boundary ...
Rui M. L. Ferreira +3 more
doaj +1 more source
Experimental study of open channel flow in a bend
Shui kexue jinzhan, 2012 Measurement of open-channel-flow in a bend was made by using particle image velocimetry to get instantaneous two-dimensional velocity data based on which the mean,three-dimensional flow fields were reconstructed.The results show the main flow deviates to
CHEN Qi-gang +3 more
doaj +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Mean curvature flow without singularities
, 2012 We study graphical mean curvature flow of complete solutions defined on subsets of Euclidean space. We obtain smooth long time existence. The projections of the evolving graphs also solve mean curvature flow.
Sáez, Mariel, Schnürer, Oliver C.
core +1 more source
Singularities of Lagrangian Mean Curvature Flow [PDF]
, 2020 Lagrangian mean curvature flow is a promising tool in the study of special Lagrangians. Though the flow has been of interest now for several decades, singularities of the flow are still not well understood, and extensions and generalisations of the flow ...
Wood, Albert
core +1 more source
The mean curvature at the first singular time of the mean curvature flow
Annales de l'Institut Henri Poincaré C, Analyse non linéaire, 2010 Consider a family of smooth immersions F( \cdot ,t):M^{n}\rightarrow \mathbb{R}^{n + 1} of closed hypersurfaces in \mathbb{R}^{n + 1} moving by the mean curvature flow \frac{\partial F(p,t)}{\partial t} = −
Le, Nam Q., Sesum, Natasa
openaire +2 more sources