Results 61 to 70 of about 41,071 (268)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mean curvature flow and isotopy problems

, 2021
Artemis-Aikaterini Vogiatzi
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Non-local interaction in discrete Ricci curvature-induced biological aggregation

Royal Society Open Science
We investigate the collective dynamics of multi-agent systems in two- and three-dimensional environments generated by minimizing discrete Ricci curvature with local and non-local interaction neighbourhoods.
Jyotiranjan Beuria, Laxmidhar Behera
doaj   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model

Frontiers in Physiology
Objective: The aim of this study is to perform specific hemodynamic simulations of idealized abdominal aortic aneurysm (AAA) models with different diameters, curvatures and eccentricities and evaluate the risk of thrombosis and aneurysm rupture.Methods ...
Lulu Wang, Xudong Jiang, Kejia Zhang, Kai Chen, Peng Wu, Xiaoqiang Li   +5 more
doaj   +1 more source

Local Well-Posedness of Skew Mean Curvature Flow for Small Data in d ≥ 4 Dimensions. [PDF]

Commun Math Phys, 2022
Huang J, Tataru D.
europepmc   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Rigidity properties of Colding–Minicozzi entropies

Advanced Nonlinear Studies
We show certain rigidity for minimizers of generalized Colding–Minicozzi entropies. The proofs are elementary and work even in situations where the generalized entropies are not monotone along mean curvature flow.
Bernstein Jacob
doaj   +1 more source

Improved flow prediction of non-ideal sonic nozzles by CFD-based surrogate modelling

Engineering Applications of Computational Fluid Mechanics
The use of sonic nozzles as a high-precision standard for gas flow measurements in various engineering and metrological applications is well-established.
Sebastian Weiss, Bodo Mickan, Kilian Oberleithner, Markus Bär, Sonja Schmelter   +4 more
doaj   +1 more source