Results 81 to 90 of about 43,248 (266)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Translating annuli for mean curvature flow

Advances in Mathematics
We construct a family of complete, properly embedded, annular translators $M$ such that $M$ lies in a slab and is invariant under reflections in the vertical coordinate planes. Each translator in the family is asymptotic as $z\to -\infty$ to four vertical planes $\{y= \pm b\}$ and $\{y= \pm B\}$, where $00$, there is a translator in the family with ...
Hoffman, David, Martín, Francisco, White, Brian   +2 more
openaire   +3 more sources

Examples of Ricci-Mean Curvature Flows [PDF]

The Journal of Geometric Analysis, 2017
Let $π:\mathbb{P}(\mathcal{O}(0)\oplus \mathcal{O}(k))\to \mathbb{P}^{n-1}$ be a projective bundle over $\mathbb{P}^{n-1}$ with $1\leq k \leq n-1$. In this paper, we show that lens space $L(k\, ;1)(r)$ with radius $r$ embedded in $\mathbb{P}(\mathcal{O}(0)\oplus \mathcal{O}(k))$ is a self-similar solution, where $\mathbb{P}(\mathcal{O}(0)\oplus ...
openaire   +2 more sources

Rigidity properties of Colding–Minicozzi entropies

Advanced Nonlinear Studies
We show certain rigidity for minimizers of generalized Colding–Minicozzi entropies. The proofs are elementary and work even in situations where the generalized entropies are not monotone along mean curvature flow.
Bernstein Jacob
doaj   +1 more source

Improved flow prediction of non-ideal sonic nozzles by CFD-based surrogate modelling

Engineering Applications of Computational Fluid Mechanics
The use of sonic nozzles as a high-precision standard for gas flow measurements in various engineering and metrological applications is well-established.
Sebastian Weiss, Bodo Mickan, Kilian Oberleithner, Markus Bär, Sonja Schmelter   +4 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A CFD Description of the Breach Flow of an Overtopped Embankment Dam

Infrastructures
We investigate the flow over a breached dam through combined measurements and numerical simulations, revealing key topological features of the mean flow, including separation and stagnation surfaces, attached vortices, secondary currents, and boundary ...
Rui M. L. Ferreira, Nuno M. C. Martins, Teresa Alvarez, Teresa Viseu   +3 more
doaj   +1 more source