Results 91 to 100 of about 6,607,246 (296)

Mean Curvature Flow with Boundary

, 2019
We develop a theory of surfaces with boundary moving by mean curvature flow. In particular, we prove a general existence theorem by elliptic regularization, and we prove boundary regularity at all positive times under very mild hypotheses.
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mean curvature flow with obstacles [PDF]

, 2012
18 pagesWe consider the evolution of fronts by mean curvature in the presence of obstacles. We construct a weak solution to the flow by means of a variational method, corresponding to an implicit time-discretization scheme. Assuming the regularity of the
M. Novaga, Almeida, Luís, Chambolle, Antonin, Novaga, M., L. Almeida, Almeida, L., Novaga, Matteo, A. Chambolle, Chambolle, A.   +8 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Role of curvature in controlling SWBLI behavior in a hypersonic double ramp flow

Frontiers in Mechanical Engineering
Hypersonic flows generate intense unsteady pressure and thermal loads, posing significant challenges for high-speed aerospace applications such as re-entry vehicles and hypersonic cruise systems.
Abhinav Aggarwal, Rajesh Ranjan
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Sharp upper bounds for the capacity in the hyperbolic and Euclidean spaces

Advances in Nonlinear Analysis
We derive various sharp upper bounds for the pp-capacity of a smooth compact set KK in the hyperbolic space Hn{{\mathbb{H}}}^{n} and the Euclidean space Rn{{\mathbb{R}}}^{n}.
Li Haizhong, Li Ruixuan, Xiong Changwei
doaj   +1 more source

Swampland, gradient flow and infinite distance

Journal of High Energy Physics, 2020
In the first part of this paper we will work out a close and so far not yet noticed correspondence between the swampland approach in quantum gravity and geometric flow equations in general relativity, most notably the Ricci flow.
Alex Kehagias, Dieter Lüst, Severin Lüst   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Non-local interaction in discrete Ricci curvature-induced biological aggregation

Royal Society Open Science
We investigate the collective dynamics of multi-agent systems in two- and three-dimensional environments generated by minimizing discrete Ricci curvature with local and non-local interaction neighbourhoods.
Jyotiranjan Beuria, Laxmidhar Behera
doaj   +1 more source