Advanced Science, EarlyView.An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan +7 more
wiley +1 more source
Mean platelet volume and clinical outcomes in patients with acute ischemic stroke: A systematic review and meta-analysis. [PDF]
J Cerebrovasc Endovasc NeurosurgCabanillas-Lazo M +8 more
europepmc +1 more source
Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2
Advanced Science, EarlyView.Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang +15 more
wiley +1 more source
Exploring the correlation between mean platelet volume-to-lymphocyte ratio and all-cause and cardiovascular mortality in cancer patients: Data from the NHANES study. [PDF]
Medicine (Baltimore)Lin P, Wang J, Xie W, Xiu S, Huang X.
europepmc +1 more source
Advanced Science, EarlyView.A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann +7 more
wiley +1 more source
Correlation of Mean Platelet Volume With Angiographic Severity in Diabetic Coronary Artery Disease: A Cross-Sectional Study. [PDF]
CureusAgarwal Y, Metgudmath A, Metgudmath V.
europepmc +1 more source
Advanced Science, EarlyView.In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu +17 more
wiley +1 more source
Association Between Mean Platelet Volume and Other Inflammatory Markers in Patients with Influenza A (H1N1). [PDF]
Eurasian J MedTüzün Z +4 more
europepmc +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Mean platelet volume-to-albumin ratio as a predictor of pathological complete response in HER2-positive breast cancer undergoing neoadjuvant chemotherapy. [PDF]
Discov OncolAyyıldız Sevim H +5 more
europepmc +1 more source