Results 1 to 10 of about 365,966 (168)

Lyophilized platelets inhibit platelet aggregation with simultaneous paradoxical promotion of platelet adhesion

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Lyophilized platelets have been explored as a potential hemostatic agent due to their long-term ambient storage capabilities that make them readily available in various scenarios.
Brian Schnoor, Anne-Laure Papa
doaj   +1 more source

BLOOD PLATELETS AS ACTIVATORS AND REGULATORS OF INFLAMMATORY AND IMMUNE REACTIONS. PART 1. BASIC CHARACTERISTICS OF PLATELETS AS INFLAMMATORY CELLS

open access: yesМедицинская иммунология, 2018
Platelets are the smallest blood cells, and yet their total volume and surface area exceed those of all types of leukocytes combined. Platelets are produced by the bone marrow megakaryocytes and megakaryocytes in the lung microvessels.
N. B. Serebryanaya   +3 more
doaj   +1 more source

Protocol for Murine/Mouse Platelets Isolation and Their Reintroduction in vivo

open access: yesBio-Protocol, 2017
Platelets and coagulation have long been known to be essential for metastasis in experimental models. In order to study the interactions between tumor cells, platelets and endothelium, we have adapted methods used in coagulation research for the ...
Jae Im, Ruth Muschel
doaj   +1 more source

Humanized mouse models for inherited thrombocytopenia studies

open access: yesPlatelets, 2023
Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis.
Xiaojie Wang   +13 more
doaj   +1 more source

Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure

open access: yesPlatelets, 2022
MYH9-related disorder (MYH9-RD) is autosomal dominant thrombocytopenia caused by mutations in the MYH9 gene, which codes for the non-muscle myosin-IIA heavy chain. We present a case of a 24-year-old Chinese man with MYH9-RD who was initially misdiagnosed
Abdul Rehman Arif   +5 more
doaj   +1 more source

Analysis of adenoviral attachment to human platelets

open access: yesVirology Journal, 2009
Background Systemic adenoviral (Ad) vector administration is associated with thrombocytopenia. Recently, Ad interaction with mouse platelets emerged as a key player determining liver uptake and platelet clearance.
Urieli-Shoval Simcha   +5 more
doaj   +1 more source

Differential expression of exosomal microRNAs in fresh and senescent apheresis platelet concentrates

open access: yesPlatelets, 2022
Patients have a high risk of suffering adverse reactions after receiving platelet products stored for 5 days. Bioactive exosomes in platelet products can be accumulated during storage, which is associated with adverse reactions.
Ziyue Mi   +7 more
doaj   +1 more source

Young steady-state rabbit platelets do not have an enhanced capacity to expose procoagulant phosphatidylserine

open access: yesPlatelets, 2018
Platelets are recognized to be physiologically and functionally heterogeneous. An example of the diversity in reactivity is the formation of a distinct subpopulation of procoagulant phosphatidylserine (PS)-exposing platelets upon activation. Platelet age
Emily C. Reddy   +4 more
doaj   +1 more source

Sex-specific relationship between blood selenium levels and platelet count in a large cohort representative of the United States population

open access: yesPlatelets, 2022
While several small studies have found that selenium deficiency is associated with low platelet counts, they lack generalizability. We used data from the National Health and Nutrition Examination Surveys collected over a 12-year period.
Neda Rehan, Rehan Qayyum
doaj   +1 more source

Platelets and Anti-platelet Therapy

open access: yesJournal of Pharmacological Sciences, 2003
Platelets play a central role in the hemostatic process and consequently are similarly involved in the pathological counterpart, thrombosis. They adhere to various subendothelial proteins, exposed either by injury or disease, and subsequently become activated by the thrombogenic surface or locally produced agonists.
Archibald McNicol, Sara J. Israels
openaire   +4 more sources

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