Results 11 to 20 of about 373,549 (269)

Young steady-state rabbit platelets do not have an enhanced capacity to expose procoagulant phosphatidylserine

open access: yesPlatelets, 2018
Platelets are recognized to be physiologically and functionally heterogeneous. An example of the diversity in reactivity is the formation of a distinct subpopulation of procoagulant phosphatidylserine (PS)-exposing platelets upon activation. Platelet age
Emily C. Reddy   +4 more
doaj   +1 more source

Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study

open access: yesPlatelets, 2022
Bacteremia frequently occurs in patients with acute cholangitis, which could increase the risk of mortality. This single-center retrospective observational study was conducted from July 2013 to July 2020 to evaluate the predictive value of platelet index
XiaoYing Chen   +3 more
doaj   +1 more source

Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial

open access: yesPlatelets, 2022
Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown.
Talia Falcão Dalçóquio   +14 more
doaj   +1 more source

Platelets and Anti-platelet Therapy

open access: yesJournal of Pharmacological Sciences, 2003
Platelets play a central role in the hemostatic process and consequently are similarly involved in the pathological counterpart, thrombosis. They adhere to various subendothelial proteins, exposed either by injury or disease, and subsequently become activated by the thrombogenic surface or locally produced agonists.
McNicol, Archibald, Israels, Sara J.
openaire   +4 more sources

Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP

open access: yesPlatelets, 2023
Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot encode proteins, and a better understanding of the complex interaction networks coordinated by ncRNAs will provide a theoretical basis for the development of therapeutics targeting the ...
Wuquan Li, Yan Lv, Yeying Sun
doaj   +1 more source

Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia

open access: yesPlatelets, 2023
High-altitude polycythemia (HAPC) can occur in individuals who are intolerant to high-altitude hypoxia. In patients with HAPC, erythrocytosis is often accompanied by a decrease in platelet count.
Zhuoya Wang   +7 more
doaj   +1 more source

Treatment inequity in antiplatelet therapy for ischaemic heart disease in patients with advanced chronic kidney disease: releasing the evidence vacuum

open access: yesPlatelets, 2023
Chronic kidney disease (CKD) is a global health problem and an independent risk factor for cardiovascular morbidity and mortality. Despite evidence-based therapies significantly improving cardiovascular mortality outcomes in the general population and ...
Frances L. Varian   +3 more
doaj   +1 more source

The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry

open access: yesPlatelets, 2023
Circulating platelets maintain low cytosolic Ca2+ concentrations. At sites of vascular injury, agonist-induced Ca2+ release from platelet intracellular stores triggers influx of extracellular Ca2+, a process known as store-operated Ca2+ entry (SOCE ...
Robert H. Lee   +3 more
doaj   +1 more source

Evaluation of human platelet granules by structured illumination laser fluorescence microscopy

open access: yesPlatelets, 2023
Many roles of human platelets in health and disease are linked to their ability to transport and secrete a variety of small molecules and proteins carried in dense (δ-) and α-granules.
Fred G. Pluthero, Walter H. A. Kahr
doaj   +1 more source

Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation

open access: yesPlatelets, 2023
Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicate the
Jacob Ranjbar   +2 more
doaj   +1 more source

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