Results 21 to 30 of about 463,872 (313)

Diagnostic and prognostic role of platelets in patients with sepsis and septic shock

Platelets, 2023
Studies investigating the prognostic role of platelets commonly include critically ill patients, whereas data regarding the prognostic impact of platelet count in patients admitted with sepsis and septic shock is limited.
Tobias Schupp, Kathrin Weidner, Jonas Rusnak, Schanas Jawhar, Jan Forner, Floriana Dulatahu, Lea Marie Brück, Ursula Hoffmann, Maximilian Kittel, Thomas Bertsch, Ibrahim Akin, Michael Behnes   +11 more
doaj   +1 more source

Platelets and Anti-platelet Therapy

Journal of Pharmacological Sciences, 2003
Platelets play a central role in the hemostatic process and consequently are similarly involved in the pathological counterpart, thrombosis. They adhere to various subendothelial proteins, exposed either by injury or disease, and subsequently become activated by the thrombogenic surface or locally produced agonists.
McNicol, Archibald, Israels, Sara J.
openaire   +4 more sources

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Ney, L., Massberg, S., Goetz, Alwin Eduard, Eichhorn, M. E.;Ney, L.;Massberg, S.;Goetz, A. E.   +4 more
core   +1 more source

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]

, 2003
Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B., Simon B. Brown, Brown, Simon B, Murray C.H. Clarke, David B. Jones, Savill, John, Brendon S. Noble, Clarke, Murray C H, Noble, Brendon S, John Savill   +9 more
core   +1 more source

What can we learn from senescent platelets, their transcriptomes and proteomes? [PDF]

, 2023
Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between the proportion of newly formed platelets in the circulation and the risk of thrombosis. However,
Vadgama, A, Timothy D. Warner, Armstrong, PC, Allan, HE, Ami Vadgama, Warner, TD, Harriet E. Allan, Paul C. Armstrong   +7 more
core   +1 more source

High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets

, 2023
Platelets are transfused to patients to prevent bleeding. Since both preparation and storage can impact the hemostatic functions of platelets, we studied platelet concentrates (PCs) with different initial composition in regard to platelet fragmentation ...
Dermot Kenny, Alshamari, Aseel,, Sandgren, Per, Mohammad R. Abedi (14394616), Vasilache, Ana-Maria, Abedi, MR, Tynngard, N, Ramstroem, S, Mohammad R. Abedi, Ramström, Sofia,, Tynngård, Nahreen,, Abedi, Mohammad R.,, Kenny, Dermot, Sofia Ramström (808839), Vasilache, Ana-Maria,, Per Sandgren, Sofia Ramström, Vasilache, Ana Maria,, Aseel Alshamari (14394607), Ana Maria Vasilache (14394613), Tynngård, Nahreen, Kenny, Dermot,, Sandgren, P,, Vasilache, AM, Aseel Alshamari, Abedi, Mohammad R., Ana Maria Vasilache, Nahreen Tynngård (686725), Dermot Kenny (202554), Alshamari, A, Ramström, Sofia, Kenny, D, Per Sandgren (14394610), Nahreen Tynngård, Sandgren, Per,, Alshamari, Aseel   +35 more
core   +1 more source

Association of immature platelets with perioperative complications in neurosurgery

Platelets, 2023
Immature platelets are newly formed platelets with an increased prothrombotic potential. This study evaluates whether immature platelets are associated with relevant complications in neurosurgical patients.
Aida Anetsberger, Isabell Bernlochner, Bettina Jungwirth, Manfred Blobner, Bernhard Meyer, Eberhard F Kochs, Dario Bongiovanni, Sebastian Schmid, Clemens Langgartner, Lea Baumgart, Jens Gempt   +10 more
doaj   +1 more source

Acidic preparations of lysed platelets upregulate proliferative pathways in osteoblast-like cells as demonstrated by genome-wide microarray analysis [PDF]

, 2011
latelets contain numerous growth factors essential for wound and fracture healing. We investigated the gene expression in human osteoblast-like cells stimulated with lysed platelets prepared in acidic, neutral, or alkaline buffers.
Söderström, Mats,, Magnusson, Per, Kalén, Anders,, Per Magnusson, Anders Kalén, Ansell, Anna, Linder, Cecilia, Kalén, Anders, Anna Ansell, Söderström, Mats, Linder, Cecilia,, Ola Wahlström, Magnusson, Per,, Cecilia Halling Linder, Ansell, Anna,, Wahlström, Ola, Mats Söderström, Wahlström, Ola,   +17 more
core   +1 more source

Immature platelets in COVID-19

Platelets, 2023
Platelets play a critical role in immune response. Coronavirus disease 2019 (COVID-19) patients with a severe course often show pathological coagulation parameters including thrombocytopenia, and at the same time the proportion of immature platelets ...
Monika Wolny, Marcus Dittrich, Cornelius Knabbe, Ingvild Birschmann   +3 more
doaj   +1 more source

Normalization of qPCR in platelets – YWHAE a potential genericreference gene

, 2016
The mRNA of human platelets has been extensively studied and it is generally appreciated that platelets contain mRNA transcripts derived from the megakaryocytes, and they have the ability to translate it into proteins.
Svensson, Per-Arne,, Erlinge, David,, Jern, Sverker,, Svensson, Per Arne,, Mossberg, Karin,, Erlinge, D., Svensson, Per Arne, Brogren, Helén,, Gidlöf, Olof,, Mossberg, Karin, Gidlof, O., Jern, Sverker, Brogren, Helén, Erlinge, David, Gidlöf, Olof, Lund University.   +15 more
core   +1 more source