Results 231 to 240 of about 12,018,315 (264)

Mean platelet volume as a Low-Cost discriminatory marker for thrombotic risk assessment in Yemeni type 2 diabetic patients: A proposal for Resource-Limited settings. [PDF]

Confl Health
Ali NT, Abdullah RS, H Mahdi MA, Ali GS, Ali HM.   +4 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Reduced mean platelet volume (MPV) as an inflammatory marker in Chinese women with polycystic ovary syndrome: a case-control study. [PDF]

BMC Womens Health
Yin Q, Liu Y, Zhang G, Cao Y, Zheng J.
europepmc   +1 more source

Stretchable h‐BN/TPU Fibers for Passive‐Active Dual‐Mode Thermal Management and Wearable Haptic Interfaces

Advanced Science, EarlyView.
Optimized 30 wt.% h‐BN/TPU fibers create a thermal conductivity of 2.08 W·m−1·K−1 while retaining mechanical compliance (422% elongation at break). Woven fabrics reduce surface temperature by 5.7°C under simulated solar irradiation. Glove integration enables localized fingertip heating at 29.55°C·s−1 with a thermal relaxation time of approximately 20 s.
Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng‐Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu   +12 more
wiley   +1 more source

Hemoglobin and mean platelet volume abnormalities in children exposed to heavy metals and metalloids in a pilot biomonitoring study. [PDF]

Sci Rep
Mendoza-Cano O, Ríos-Silva M, Gonzalez-Curiel IE, Camacho-delaCruz AA, Romo-García MF, Bricio-Barrios JA, Cuevas-Arellano HB, Quintanilla-Montoya AL, Martínez-Preciado MA, Rincón-Avalos P, Hilerio-López ÁG, Uribe-Ramos JM, Benites-Godinez V, Murillo-Zamora E.   +13 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Association of mean platelet volume-to-platelet count ratio for 24-hour mortality in patients with severe trauma. [PDF]

Medicine (Baltimore)
Ryu S, Lee D, Lee J, Lee B.
europepmc   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Platelet Lymphocyte Ratio and Mean Platelet Volume as Predictive Biomarkers for Spontaneous Passage of Distal Ureteric Stones in Patients Undergoing Medical Expulsive Therapy. [PDF]

Cureus
Patil S, Patil S, Kundargi VS, Dhruva HM, Vinayak R, Kumar G, Negi KK.   +6 more
europepmc   +1 more source

Clinical values of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, red blood cell distribution width and mean platelet volume in neonatal pulmonary infections. [PDF]

Pak J Med Sci
Du J, Shi Q.
europepmc   +1 more source