Liposomal Drug Delivery in Ocular Therapy: Strategies for Enhancing Corneal Penetration and Bioavailability. [PDF]
Mehta P, Moore E, Dash A, Shukla S.
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Lévy Formulation of the Stochastic Theory of Chromatography and Extension to Phase-Type Markov Renewal Process. [PDF]
Mirzahosseini A +3 more
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Empowering early breastfeeding: Determinants of timely initiation among the infants in a rural Indian medical centre. [PDF]
Mashalkar DM +5 more
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Nim1-related kinases regulate septin organization and cytokinesis by modulating Hof1 at the cell division site. [PDF]
Bhojappa B +7 more
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A multifactorial model of factors associated with PTSD, anxiety and depression among migrants in Spain. [PDF]
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Mean residence time in organs in toxicokinetic studies
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Mean residence time in the body versus mean residence time in the central compartment
Journal of Pharmacokinetics and Pharmacodynamics, 1985Mean residence time in the body may be determined by noncompartmental methods following any type of input process into the sampled compartment. Mean residence time in the central compartment can be determined following an intravenous bolus dose, as it requires calculation of the concentration at zero time. For any other input process the mean residence
Leslie Z Benet
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Definition of mean residence times in pharmacokinetics
Biopharmaceutics and Drug Disposition, 1987AbstractA new definition of the mean residence time is proposed which includes the commonly used definition as a special case. The advantage of the new definition is that it applies for both linear and non‐linear systems. Some practical advantages which follow from the new definition are discussed.
D J Cutler
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Mean residence time in peripheral tissue
Journal of Pharmacokinetics and Pharmacodynamics, 1987The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.
Joseph C Fleishaker, P J McNamara
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