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Biopharmaceutics & Drug Disposition, 1988
AbstractMean residence times (MRTs) have been classified into two main groups, namely system moment MRT [MRT(S,MO] and system matrix MRT [MRT(S,MA]. There are also MRTs of individual compartments [MRT(i)] such as central or plasma compartment, [MRT(P)], and tissue compartments and the MRT of an absorption site, [MRT(A)].
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AbstractMean residence times (MRTs) have been classified into two main groups, namely system moment MRT [MRT(S,MO] and system matrix MRT [MRT(S,MA]. There are also MRTs of individual compartments [MRT(i)] such as central or plasma compartment, [MRT(P)], and tissue compartments and the MRT of an absorption site, [MRT(A)].
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Mean residence time in multicompartmental models with time delays
Journal of Biomedical Engineering, 1993Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any n-compartmental models which may ...
Y, Plusquellec, G, Houin
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Definition of mean residence times in pharmacokinetics
Biopharmaceutics & Drug Disposition, 1987AbstractA new definition of the mean residence time is proposed which includes the commonly used definition as a special case. The advantage of the new definition is that it applies for both linear and non‐linear systems. Some practical advantages which follow from the new definition are discussed.
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Mean residence time of plutonium in the troposphere
Environmental Science & Technology, 1982Plutonium is injected into the stratosphere by large atmospheric thermonuclear explosions. When aerosols bearing plutonium reenter the troposphere, they are removed by such processes as rainfall and sedimentation. In this work, the mean tropospheric residence time of stratospherically injected plutonium is calculated.
Robert W. Holloway, David W. Hayes
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On mean residence times in flow systems
Chemical Engineering Science, 1983Abstract A widely accepted result of residence time theory namely mean residence time is equal to the system volume divided by the flow rate was first offered by Danckwerts[l] and later extended by Buffham[21 and Gibilaro[3] to more general cases.
R.C. Awasthi, K. Vasudeva
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Methods and findings in experimental and clinical pharmacology, 1986
The definition of mean residence time in the strict sense of mathematical statistics is deduced. It is demonstrated that the area-normalized concentration time curve is an estimate of the probability density function for residence times of drug molecules in the pharmacokinetic system, provided that the area under the concentration-time profile is ...
D, Brockmeier, H M, von Hattingberg
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The definition of mean residence time in the strict sense of mathematical statistics is deduced. It is demonstrated that the area-normalized concentration time curve is an estimate of the probability density function for residence times of drug molecules in the pharmacokinetic system, provided that the area under the concentration-time profile is ...
D, Brockmeier, H M, von Hattingberg
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Sampling strategies for noncompartmental estimation of mean residence time
Journal of Pharmacokinetics and Biopharmaceutics, 1983An optimization procedure is presented for selecting sample times for estimating mean residence time using noncompartmental data analysis. Performance of this experimental design strategy is evaluated using Monte Carlo simulations of a model for digoxin kinetics.
D Z, D'Argenio, D, Katz
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Dosage Intervals Based on Mean Residence times
Journal of Pharmaceutical Sciences, 1987It is shown that a suitable dosage interval, tau, can be estimated by a factor times the sum of the mean residence time (MRT) of the central compartment (MRTC) and the MRT of the absorption site (MRTA). This value of tau will provide a ratio, maximum steady-state plasma concentration: minimum steady-state plasma concentration, which averages ...
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Mean residence time: Some further consideration
Biopharmaceutics & Drug Disposition, 1989AbstractThe correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.
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Mean residence time by hierarchical clustering analysis
Theoretical Chemistry Accounts, 2016A revised method, based on the hierarchical clustering data analysis technique, is proposed as an improved approach to estimate the mean residence time (MRT) related to the interaction between a molecule and its solvent as described via molecular dynamics simulations.
L. Guzzardi +4 more
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