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Mean residence time for drugs subject to enterohepatic cycling
Journal of Pharmacokinetics and Biopharmaceutics, 1989A physiologically realistic model of enterohepatic cycling (EHC) which includes separate liver and gallbladder compartments, discontinuous gallbladder emptying and first-order absorption from both an oral formulation and secreted bile (kapo and kab, respectively) has been developed.
Shepard, Theresa A. +3 more
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Mean residence time: Some further consideration
Biopharmaceutics & Drug Disposition, 1989AbstractThe correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.
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Sampling strategies for noncompartmental estimation of mean residence time
Journal of Pharmacokinetics and Biopharmaceutics, 1983An optimization procedure is presented for selecting sample times for estimating mean residence time using noncompartmental data analysis. Performance of this experimental design strategy is evaluated using Monte Carlo simulations of a model for digoxin kinetics.
D Z, D'Argenio, D, Katz
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Residence Times and Mean Concentrations
1985The residence time T of a single particle is the time spent in the atmosphere of that particle. From the definitions in section 3 it follows that $$ E(c(t))\, = \,\int\limits_{ - \infty }^t {E(e^{ - (\Lambda (t) - \Lambda (s))} dq(s))} . $$
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Dosage Intervals Based on Mean Residence times
Journal of Pharmaceutical Sciences, 1987It is shown that a suitable dosage interval, tau, can be estimated by a factor times the sum of the mean residence time (MRT) of the central compartment (MRTC) and the MRT of the absorption site (MRTA). This value of tau will provide a ratio, maximum steady-state plasma concentration: minimum steady-state plasma concentration, which averages ...
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Mean residence time by hierarchical clustering analysis
Theoretical Chemistry Accounts, 2016A revised method, based on the hierarchical clustering data analysis technique, is proposed as an improved approach to estimate the mean residence time (MRT) related to the interaction between a molecule and its solvent as described via molecular dynamics simulations.
L. Guzzardi +4 more
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Mean Residence Time of a Liquid in a Trickling Filter
Journal of the Sanitary Engineering Division, 1959Pilot plant research studies aimed at broadening the basic knowledge relative to the performance of trickling filters were initiated. This paper presents the results of initial hydraulic studies in which the mean residence time was determined for tap water applied to columns packed with spherical media under conditions of varying hydraulic loading ...
Morton D. Sinkoff +2 more
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A method for calculating the mean residence times of catenary metabolites
Biopharmaceutics & Drug Disposition, 1991AbstractA method for calculating the mean residence times of metabolites in the body, systemic circulation, and peripheral tissue is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration versus time curves of the metabolite and its precursor.
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A derivation of mean residence time.
European journal of drug metabolism and pharmacokinetics, 1992MRT was derived as the mean value of the continuously distributed random variable residence time. Provide that elimination kinetics is linear and that elimination takes place exclusively from the central compartment, MRT can be calculated from the ratio AUMC/AUC.
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Derivation of Mean Cell Residence Time Formula
Journal of Environmental Engineering, 1998Mean cell residence time or MCRT has emerged as the leading design and operation parameter for suspended growth wastewater treatment processes. The commonly used MCRT formula has never been shown to represent the time the microorganisms spend in the system.
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