Results 131 to 140 of about 291,506 (257)

School-age lung function after preterm birth: early-life determinants in a paediatric pulmonology cohort with comparison with NHANES. [PDF]

Thorax
Kelchtermans J, Rice JL, Aoyama BC, Collaco JM, McGrath-Morrow S.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Association between residual gastric volume and long-term postoperative sleep disturbances in gastric cancer survivors. [PDF]

Front Oncol
Fan L, Li S, Meng T, Zhang S, Feng H.
europepmc   +1 more source

Beyesian Statistical Inference on Mean Residual Life Function

, 2016
The mean residual function is very important in survival analysis, where lifetime distributions that model the time to a particular event are studied. This includes machine failure times, service and repair times, and event duration times, in general. The mean residual function provides the expected remaining life of lifetime distributions given that ...
openaire  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Seasonal metabolic and growth responses of grazing beef heifers divergent in residual feed intake. [PDF]

PLoS One
Londono-Mendez MC, Lasso-Ramirez S, Fitzsimmons C, Plastow G, Bork EW, Basarab J, Vasco ACCM, Silva AEM, Macias Franco A, Vinsky M, Li C, Medeiros da Silva G.   +11 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Residual daytime sleepiness in patients with obstructive sleep apnoea syndrome: A service review in a tertiary sleep centre. [PDF]

Sleep Breath
Kaler JS, Chakrabarti B, Craig S, Steier J.   +3 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Effects of Monocular Perceptual Learning on Eye-Specific Cortical Activity in Residual Anisometropic Amblyopia: Evidence From EEG Asymmetry. [PDF]

Invest Ophthalmol Vis Sci
Xu Z, Zhou Y, Pang Y, He Y, Yu W, Zhong Y, Li Q, Ye Q, Yuan J, Qiu X, Wen Y, Li J.   +11 more
europepmc   +1 more source