Results 41 to 50 of about 5,140,391 (304)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Adjusted variance estimators based on minimizing mean squared error for stratified random samples

Statistical Theory and Related Fields
In the realm of survey data analysis, encountering substantial variance relative to bias is a common occurrence. In this study, we present an innovative strategy to tackle this issue by introducing slightly biased variance estimators.
Guoyi Zhang, Bruce Swan
doaj   +1 more source

Comparisons of the Performances of Estimators of a Bounded Normal Mean Under Squared-Error Loss

Revstat Statistical Journal, 2009
This paper is concerned with the estimation under squared-error loss of a normal mean θ based on X ∼ N (θ, 1) when |θ| ≤ m for a known m > 0. Nine estimators are compared, namely the maximum likelihood estimator (mle), three dominators of the mle ...
Yiping Dou , Constance van Eeden
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Attack-Resilient Minimum Mean-Squared Error Estimation [PDF]

, 2014
This work addresses the design of resilient estimators for stochastic systems. To this end, we introduce a minimum mean-squared error resilient (MMSE-R) estimator whose conditional mean squared error from the state remains finitely bounded and is ...
Sokolsky, Oleg, Lee, Insup, James Weimer, Nicola Bezzo, Weimer, James, Oleg Sokolsky, Pajic, Miroslav, Insup Lee, Miroslav Pajic, Bezzo, Nicola   +9 more
core   +1 more source

Implementation of the Fuzzy Tsukamoto Method for Office Stationery Estimation Stock System

Jurnal Riset Informatika, 2022
Information technology supports the company's operational activities in recording incoming goods, outgoing goods, and existing inventory. PT. Mitraniaga Distribusindo is a company engaged in food distribution, which includes supporting aspects for smooth
Tedy Rukmana, Hersanto Fajri, Dahlia Widhyaestoeti   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Investigation of the efficiency of support vector machine in predicting changes in water quality parameters (Case study: Choghakhor International Wetland) [PDF]

بوم‌شناسی آبزیان, 2020
Inland waters, such as wetlands, are considered to be sensitive ecosystems, and sustainable productivity can only be achieved by adopting an appropriate environmental approach.
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doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source