Results 51 to 60 of about 248,461 (262)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Backpropagation Neural Network Algorithm for Optimizing Network Bandwidth Allocation Based on User Access Patterns

Engineering Proceedings
In the era of rapid digital transformation, efficient network bandwidth allocation is vital for ensuring high-quality service and seamless network operations, particularly in environments with dynamic traffic patterns.
Akmal Nuur Fauzan, Mohammad Sahal Assahari, Abdul Rahman Jainun, Somantri   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Estimating misclassification error: a closer look at cross-validation based methods

BMC Research Notes, 2012
Background To estimate a classifier’s error in predicting future observations, bootstrap methods have been proposed as reduced-variation alternatives to traditional cross-validation (CV) methods based on sampling without replacement.
Ounpraseuth Songthip, Lensing Shelly Y, Spencer Horace J, Kodell Ralph L   +3 more
doaj   +1 more source

Bootstrapping the Mean Integrated Squared Error

Journal of Multivariate Analysis, 1993
Let \(X_ 1,\dots,X_ n\) be a sequence of i.i.d. real random variables from an unknown density \(f\). For a given kernel \(K\) and a bandwidth \(h>0\), denote with \(f_ h\) the associated Parzen-Rosenblatt estimator of \(f\). There exists a huge literature on how to choose \(h\) in an optimal way.
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ensemble Averaging and Mean Squared Error

Journal of Climate, 2016
Abstract In fields such as climate science, it is common to compile an ensemble of different simulators for the same underlying process. It is a striking observation that the ensemble mean often outperforms at least half of the ensemble members in mean squared error (measured with respect to observations). In fact, as demonstrated in the
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A Mean Weighted Squared Error-based Neural Classifier for Intelligent Pattern Recognition in Smart Grids

International Journal of Electrical Power & Energy Systems
Supervised learning is widely used in pattern recognition and classification due to its strong ability to enhance data accuracy. Loss functions have proven to be a critical factor in enhancing the predictive accuracy of intelligent classifiers with ...
Mehdi Khashei, Mehrnaz Ahmadi, Fatemeh Chahkoutahi   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source