Results 51 to 60 of about 974,381 (216)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Adjusted variance estimators based on minimizing mean squared error for stratified random samples

Statistical Theory and Related Fields
In the realm of survey data analysis, encountering substantial variance relative to bias is a common occurrence. In this study, we present an innovative strategy to tackle this issue by introducing slightly biased variance estimators.
Guoyi Zhang, Bruce Swan
doaj   +1 more source

Egg Incubator Temperature and Humidity Control Using Fuzzy Logic Controller

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2023
Controlling room temperature and humidity in egg incubator systems is a process that is widely used in the farm. A good temperature and humidity for standard egg hatching is between 35℃ – 40℃, with humidity in the machine ranging from 50%-60%.
Yulian Zetta Maulana, Firdaus Fathurrohman, Gunawan Wibisono   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Investigation of the efficiency of support vector machine in predicting changes in water quality parameters (Case study: Choghakhor International Wetland) [PDF]

بوم‌شناسی آبزیان, 2020
Inland waters, such as wetlands, are considered to be sensitive ecosystems, and sustainable productivity can only be achieved by adopting an appropriate environmental approach.
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doaj  

On the Statistical Analysis of the Harmonic Signal Autocorrelation Function

International Journal of Applied Mathematics and Computer Science, 2021
The article presents new tools for investigating the statistical properties of the harmonic signal autocorrelation function (ACF). These tools enable identification of the ACF estimator errors in measurements in which the triggering of the measurements ...
Sienkowski Sergiusz, Krajewski Mariusz
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Genetic Algorithm Assisted Error Probability Optimisation for Beamforming

, 2004
A novel Genetic Algorithm (GA) assisted direct error probability optimisation technique is proposed for adaptive beamforming, which reduces the achievable error probability by nearly two orders of magnitude at a signal-to-noise ratio of 10dB in the ...
Ahmad, N.N., Chen, S., Hanzo, L., Wolfgang, A.   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source