Results 201 to 210 of about 1,360,767 (269)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Intravenous ferric carboxymaltose and exercise capacity in iron-deficient kidney transplant recipients: a randomised, placebo-controlled trial in the Netherlands. [PDF]

open access: yesEClinicalMedicine
Vinke JSJ   +17 more
europepmc   +1 more source

Adherence to antiretroviral therapy and drug resistance impact evolving viral suppression among a cohort of children and adolescents living with perinatal HIV infection in western Kenya. [PDF]

open access: yesPLoS One
Vreeman R   +14 more
europepmc   +1 more source

On the Mean Time between Failures for Repairable Systems

IEEE Transactions on Reliability, 1986
Much of the recent work on modelling repairable systems involves Poisson processes with nonconstant intensity functions, viz, nonhomogeneous Poisson processes. Since times between failures are not identically distributed when the process is nonhomogeneous, it is not clear what concept should take the place of the mean time between failures in assessing
Engelhardt, Max, Bain, Lee J.
openaire   +2 more sources

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