Results 121 to 130 of about 901,213 (331)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Estimation of Mean Time between Failures of a Two Tandem Mill of a Sugar Plant
, 2022 Prof. Sachin N. Patil
openalex +1 more source
Fault detection using a two-model test for changes in the parameters of an autoregressive time series [PDF]
This article describes an investigation of a statistical hypothesis testing method for detecting changes in the characteristics of an observed time series.
Scholtz, P., Smyth, P.
core +1 more source
Space Transportation System Availability Relationships to Life Cycle Cost [PDF]
, 2009 Future space transportation architectures and designs must be affordable. Consequently, their Life Cycle Cost (LCC) must be controlled. For the LCC to be controlled, it is necessary to identify all the requirements and elements of the architecture at the
Chen, Timothy T. +2 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Methodology for Studying the Reliability of Interlocking Devices in Bulgarian Railways
Applied SciencesRailway signalling systems must ensure the safe movement of trains and the reliability of the operation of their components is of utmost importance.
Emiliya Dimitrova, Vasil Dimitrov
doaj +1 more source
Lower Confidence Limit for Mean Time between Failures in a System Featuring Repairable Components [PDF]
, 2018 Igor Pavlov +3 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cybernetics and Information Technologies, 2016 The present article models and examines k˅n systems, in particular Triple modular redundancy (2˅3) and 3˅5. The aim of the study is to derive mathematical models, which are used for determining the impact of structural redundancy (the number of channels ...
Hristova Mariya
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source