Results 131 to 140 of about 901,213 (331)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Applying a Data Analytics Approach to Medical Equipment Maintenance Management to Improve the Mean Time Between Failure and Availability [PDF]
, 2023 Mohammad D. AL-Tahat +77 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Vestnik MGTUIn the process of designing in-plant power supply systems, it is necessary to determine their rational redundancy. The reliability of the power supply system has been established for the following variants of the circuit of two-transformer 10/0.4 kV ...
Petrova R. M., Gracheva E. I.
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Reliability of Dubbed Technical Systems with Built-In Control Device
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2013 The paper substantiates a selection of passive or active system for dubbing technical systems in accordance with characteristics pertaining to probability of no-failure operation and mean–time-between failures with due account of non-reliability of a ...
V. A. Anishchenko +2 more
doaj
IET Intelligent Transport SystemsThe article examines the assessment of the reliability of shipboard radio navigation systems under the influence of degradation factors, with a focus on the impact of both gradual and sudden failures on the continuity of navigation equipment.
Oleksiy Melnyk +6 more
doaj +1 more source
Frontiers in Pain ResearchBackgroundPeripherally inserted central catheter (PICC) are a necessary procedure for preterm newborns care. Despite the use of analgesic treatments, its insertion can be painful.
Audrey Flours +10 more
doaj +1 more source