Results 161 to 170 of about 901,213 (331)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

An Integrated Risk-Informed Multicriteria Approach for Determining Optimal Inspection Periods for Protective Sensors. [PDF]

Sensors (Basel)
Mateus RJG, Assis R, Carmona Marques P, Martins ADB, Rodrigues JCA, Pinto FS.   +5 more
europepmc   +1 more source

Penerapan Metode Mean Time Between Failure dan Mean Time to Repair dalam Pemeliharaan Prediktif Mesin Compressor Kobelco Dengan Integrasi Sistem Monitoring Berbasis Internet of Things (Iot) di PT Suzuki Indomobil Motor

Wisnu Dwi Wibowo, Yayan Heru Haerudin, Osep Hijuzaman   +2 more
openalex   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Widespread abyssal turbidites record megathrust earthquake-triggered landslides and coseismic deformation in the Cascadia subduction zone. [PDF]

Sci Adv
Hill JC, Watt JT, Paull CK, Caress DW, Brothers DS, Arizmendi K, Gwiazda R, Kluesner J, Lundsten E, Nieminski NM, Padgett JS, Paduan JB, Snyder G.   +12 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Voronoi-Diagram-Based Load Transfer Rule: An Application to Damage Evolution in Suddenly Loaded Arrays of Pillars. [PDF]

Materials (Basel)
Domański Z, Derda T.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Dynamics of excitability in axonal trees. [PDF]

Biophys J
Cohen LD, Galateanu T, Marom S.
europepmc   +1 more source

A Comparative Study of the Parameter Estimation Method about the Software Mean Time Between Failure Depending on Makeham Life Distribution

, 2017
Hee Cheul Kim, Song Chul Moon
openalex   +2 more sources