Results 171 to 180 of about 89,725,173 (290)

The post-activation performance enhancement of sub-maximal load back squat with varied range of motion and intra-set fatigue on jump height in trained males. [PDF]

PLoS One
Xu P, Zhao L, Tan C, Li D, Xie L, Han W.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Predictors of Failure After Two-Stage Revision for Periprosthetic Joint Infections of the Knee. [PDF]

Arthroplast Today
Mulpur P, Jayakumar T, Rajeev Reddy K, S J K, Hippalgaonkar K, Reddy AVG.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Derivation and Exploratory Evaluation of the Respiratory Rate-Oxygenation (ROX) Index as a Predictor of High-Flow Nasal Cannula Outcomes in Patients With COVID-19 Pneumonia. [PDF]

Cureus
Chandra R, Ankita, Kumar H, Kumar S, Kaushal A, Jain A, Sinha N.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Preliminary results of a single, easy-to-use device for multimodal detection of intervals associated with heart failure decompensation. [PDF]

Eur Heart J Digit Health
Sánchez-Ortiz D, Rivas-Lasarte M, Nistal-Juarez A, Blanco-Tapia L, Fribourg M, Gómez-Bueno M, Hernández-Pérez FJ, Mitroi C, Martin-Centellas A, Garrido-González R, Santos-González M, Segovia-Cubero J.   +11 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Clinical Performance of High-Impact 3D-Printed Denture Resins: A Multicenter Cohort With Survival Analysis. [PDF]

Cureus
Kukucka ED, Rawal S, Youssef N, Judge A, Dartez J, Kurtzman GM.   +5 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source