Results 161 to 170 of about 89,725,173 (290)

Using Restricted Mean Time Lost to Evaluate the Prognostic Effects on Locally Advanced Breast Cancer Considering Competing Risks [PDF]

Zhaojin Li,1 Di Liu,2 Yawen Hou,3 Zheng Chen1,4 1Department of Biostatistics, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, People’s Republic of China; 2Department of ...
Li Z, Chen Z, Liu D, Hou Y
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Flow Index Trajectories During Spontaneous Breathing Trials Are Associated With Extubation Failure: A Latent Class Trajectory Modeling Study. [PDF]

Clin Transl Sci
Shen J, Liu J, Liu C, Fu X, Xu M, Yan F, Yang S, Luo Y, Lu S, Luo J, Huang X, Li Y, Pan C.   +12 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Failure Rate After Shoulder Stabilization Procedures in the Military With Use of Knotless Suture Tape: A Case-Control Study. [PDF]

Orthop J Sports Med
Feeley SM, Yow BG, Hoyt BW, Koo CJ, Wade SM, Dickens JF, Waltz RA, Rue JH, LeClere LE.   +8 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Biomechanical Comparison of Patellar Fixation Techniques in Medial Patellofemoral Ligament Reconstruction: A Pediatric Cadaveric Study. [PDF]

Orthop J Sports Med
Khoo B, Baird HBG, Alawa J, Alayleh A, Johnstone T, Chan C, Shea KG.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Durability and Failure Mechanisms of Cervical Deformity Correction Surgery. [PDF]

Global Spine J
Kucherina A, Eastlack R, Smith JS, Hamilton DK, Daniels A, Klineberg E, Passias P, Bess S, Shaffrey C, Schwab FJ, Lafage V, Lee SH, Persaud SG, Mastrokostas P, Ames C, Lau D, Protopsaltis TS, International Spine Study Group (ISSG).   +17 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source