Results 141 to 150 of about 1,753,183 (313)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

From defense to reconstruction: The hostility-meaning dual-path model of how observing others' adversity influences distress disclosure. [PDF]

PLoS One
Zhang X, Huang T, Wang Y, Hou Z, Fu J.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Exploring meaning in culture: Insights from meaning-centered psychotherapy in Aotearoa, New Zealand. [PDF]

Palliat Support Care
Clayden C, Wells A, Applebaum AJ, Reynolds L.   +3 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The relationship between physical activity and depressive symptoms in college students: the sequential mediation effects of emotion regulation self-efficacy and sense of life meaning. [PDF]

Front Psychol
Chen W, Liu H, Xu J, Si M, Zhong X, Li T, Zhu F.   +6 more
europepmc   +1 more source

Electronic Public Service Delivery: Exploring the Use of Focus Groups for Ex ante Program Evaluation

, 2004
Eugène Loos, LSG Management of Meaning (MOM), Management of Meaning, Traunmüller, R., Loos, E.F., Universiteit Utrecht   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Meaning search as a mediator between post-traumatic stress symptoms and burnout in the long-term recovery phase after the 2023 Kahramanmaraş earthquakes. [PDF]

Front Public Health
Çınaroğlu M, Yılmazer E.
europepmc   +1 more source

Meaning making amongst South African survivors of violent crime

, 2007
Includes bibliographical references (leaves 93-102)The aim of this study was to explore the meaning attributions, in terms of comprehensibility and significance, held by South African crime survivors in relation to the traumatic event, and to see if ...
Thacker, Mandy
core