FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
What is the normativity of Meaning?
There has been much debate over whether to accept the claim that meaning is normative. One obstacle to making progress in that debate is that it is not always clear what the claim amounts to.
Whiting, Daniel
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Supporting the Integration of the Existential Dimension Into Clinical Practice: Health Care Providers' Experiences With a Meaning-Making Synopsis of Patients Living Long-Term With Incurable Cancer. [PDF]
PsychooncologyVisser A +4 more
europepmc +1 more source
Process, Image, and Meaning A realistic model of the meaning of sentences and narrative texts
The general topic of this book is the development of a "realistic" model of meaning; it has to account for the ecological basis of meaning in perception, action, and interaction, and is realistic in the sense of "scientific realism", i.e.
Wildgen, Wolfgang.
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Interpretation of the assiciative meaning in the lyric of Maher Zain's selected song
, 2016 this thesis is about interpretation of the assiciative meaning in the lyric of Maher Zain's selected song. the method used descriptive qualitative, the instrumen of research was note taking which data colletion were interpreted in four ways such as ...
Kurniawan
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Reciprocal Associations Between Growth Mindset and Adolescent School Life Satisfaction: The Longitudinal Mediation Effect of Meaning in Life. [PDF]
Psychol Res Behav ManagZhao X, Xin T, Sang Q.
europepmc +1 more source