Results 91 to 100 of about 115,279,540 (302)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Life-meaning, psychological health, and well-being
, 2017 The overall aim of this thesis is to investigate the relationship between meaning in life and psychological health, including both psychopathology and well-being.
Gerschman, Elliot Samuel Michael (3703516)
core +1 more source
Effects of perceived stress on college students’ sleep quality: a moderated chain mediation model
BMC PsychologyBackground Perceived Stress has been shown as a key contributor to sleep quality, but the underlying mechanism between perceived stress and sleep quality remains unknown.
Yaqing Huang +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Mediating Role of Self-Esteem Between Meaning in Life and Social Media Addiction
The advent of digital technologies has markedly transformed human interactions and communication. While social media platforms facilitate connectivity and information sharing, their compelling features, such as instant notifications and one-click ...
Berhan Akdağ, Cansu Ünsal
core +1 more source
Meaning-making processes among bereaved mothers who have lost a child to cancer [PDF]
, 2007 Includes bibliographical references (leaves 86-93).The loss of a child constitutes a crisis of meaning, as prior meaning structures and fundamental assumptions about the world are shattered, and the natural order of life and death is undennined ...
Lipshitz, Marc
core +1 more source
Psychiatry InternationalIntroduction: Nurses in hospital settings frequently experience anxiety, which may adversely affect both their psychological well-being and professional functioning.
Vasiliki Tsoulou +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Exploring travel and spirituality: The role of travel in facilitating life purpose and meaning within the lives of individuals [PDF]
, 2010 This thesis is a phenomenological study of individuals who engaged in tours provided by Hands Up Holidays, a tour operator marketing their travel as ‘spiritual’.
Willson, Gregory Brian +1 more
core