Results 101 to 110 of about 506,706 (314)
Meaning in Life as a Source of Entertainment
, 2013 In this paper we mean to introduce into the field of entertainment computing an overview of insights concerning fundamental human needs. Researchers such as Hassenzahl and Desmet, discuss design approaches based on psychological insights from various and varied sources.
Robby van Delden, Dennis Reidsma
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Values and life-meaning orientations of troubled teenagers [PDF]
, 2023 Людмила Валентиновна Косикова
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Meaning of Life in People With Leukemia in Tehran, Iran: A Descriptive Study [PDF]
نشریه پرستاری ایرانBackground & Aims Diagnosis with cancer can change the meaning of life. When people with cancer correctly perceive the meaning of life, they learn how to fight the disease and finally.
Marjan Ahmadi +3 more
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Acta PsychologicaThis cross-sectional study aimed to examine the mechanism underlying the association between of meaning-focused coping on depression in everyday contexts.
Yaogfei Song, Ying Luo, Ronghua Zhang
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, 2018 This article considers Ayer’s two main statements on the meaning of life; the first written in the prime of life, and the second at the end of life. The first, which is the focal point of this article, is heavily influenced by scienticism, and attempts to show that the question of the meaning of life is meaningless, rather as Ayer had earlier tried to ...
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Translation and Validation of the German Version of the Ikigai-9
SocietiesBackground: The Japanese concept of “ikigai” embodies the feeling of having a meaningful purpose in life. It is associated with several positive outcomes.
André Hajek +3 more
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