Results 121 to 130 of about 674,697 (350)

Curiosity in Later Life: Identifying Psychosocial Predictors Using Random Forest Modeling

Societies
Curiosity supports adaptive cognitive and psychological functioning across the lifespan, yet prior research suggests that some dimensions of curiosity decline with age, and little is known about the psychosocial and lifestyle factors that are associated ...
Shyhnan Liou, Cyleen A. Morgan
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Mortality and Meaningfulness

, 2018
Some have claimed that human life is inevitably meaningless because we are mortal. Others have claimed the opposite: that life would be meaningless if we never died, and our being mortal is actually an essential condition for our lives to have any ...
Thomas, Joshua
core  

Towards metrics of meaningfulness for tech practitioners

, 2019
HCI and the tech industry are increasingly interested in designing products that afford meaningful user experiences. Yet while several metrics of meaningfulness have been suggested, their utility and relevance for industry is unclear.
Mekler, Elisa D., Elisa D. Mekler, Vanessa Julia Carpenter, Carpenter, Vanessa Julia   +3 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Datification and the pursuit of meaningfulness in work [PDF]

, 2019
Proliferation of digital means of tracking worker activities has contributed to the rise of data-driven approaches to managing people, with employees often required to record their activities for accountability purposes.
Pamela Tierney, Robert D. Galliers, Tierney, Pamela, Wagner, Erica L., Sue Newell, Mari‐Klara Stein, Newell, Susan, Stein, Mari-Klara, Newell, Sue, Galliers, Robert D., Erica L. Wagner   +10 more
core   +1 more source

The Processes of Inclusion and Exclusion in Physical Education: A Social-Relational Perspective

Social Inclusion, 2015
Existing research on inclusion and exclusion processes in physical education (PE) has particularly focused on exclusion from PE as something being done to students and attributed to specific social categories such as (female) gender, (low) physical ...
Mette Munk, Sine Agergaard
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Affect and Meaningfulness as Variables in Mediate Association

, 1972
Affect and meaningfulness in verbal mediation were studied. The design of the study included Phase I, which varied the affect levels (high and low) while holding meaningfulness constant at a medium level, and Phase II, which varied both the affect level
James A. Aagard, David R. Stone
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source