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pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source

Study on the development of motor aerobic endurance through specific means of playing football in secondary school students

Annals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement
The theoretical importance of the paper lies in the fact that it carries out a proper analysis of the theoretical concepts related to the motor quality endurance, the content of the school curriculum related to endurance and the specific training methods
GROSU Bogdan-Marius
doaj +1 more source

Statistical Aspects in the Achievement of the Training Models for the Development of the Coordination [PDF]

Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2010
The technico-tactical preparation of the young players with the age of 13-14 years will be oriented in the view of the improvement and the perfection of each play element in part, in time what the strictly speaking game will especially serve as mean of ...
Aurelian DRAGAN
doaj

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source

Oral History Interview: Elizabeth Means

, 1989
These are a part of a series of interviews which Diana Parnicza conducted in the course of her project concerning Appalachian caregivers. Elizabeth Means (referred to in the interview as Caregiver #10) discusses: her family; a series of true/false ...
Means, Elizabeth
core +1 more source

STUDY REGARDING THE DEVELOPMENT OF AMBIDEXTROUS AT MIDDLE SCHOOL CLASSES, USING METHODS THAT ARE SPECIFIC TO FOOTBALL GAME [PDF]

Annals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement, 2018
Technical training to junior or grades of secondary school is the essential element in the qualitative development of future football players equally in this phase of training should focus on developing the skills driving specific football game, made ...
Grosu Bogdan-Marius
doaj

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source

[Darwinism and the meaning of "meaning"].

Asclepio; archivo iberoamericano de historia de la medicina y antropologia medica, 2009
The problem of the meaning of life is herewith contemplated from a Darwinian perspective. It is argued how factors such as existential depression, the concern about the meaning of ‘meaning’, the problem of evil, death as the end of our personal identity, happiness as an unachievable goal, etc. may well have an adaptive dimension ‘controlled’ neither by
openaire +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source

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