Results 101 to 110 of about 16,568,157 (301)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Comprehensive program of increase of efficiency of locomotive park JSC RZHD
Вестник СибАДИ, 2017 The authors propose a comprehensive program of unification into a single system all processes of the life cycle of locomotives that reduce costs associated primarily with the operation and maintenance of a locomotive fleet of JSC "Russian Railways".
P. N. Rubezhanski, A. V. Davydov
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Geometric Construction of Some Lehmer Means
Mathematics, 2018 The main aim of this paper is to contribute to the recently initiated research concerning geometric constructions of means, where the variables are appearing as line segments.
Ralph Høibakk +3 more
doaj +1 more source
A Means to an End, A Means to an End, A Means to an End: Repetition through two filmmakers and four films [PDF]
, 2017 Wong Kar-wai is an auteur whose body of work constitutes over 20+ short and feature films. Wong is a Hong Kong director with a unique audio-visual style.
Buzzell, Alec O.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Improvement of the organization of Federal contract system of purchases
Путеводитель предпринимателя, 2020 In article questions and problems of a choice of reliable commercial partners are considered at implementation of purchases for the state and municipal structures of the goods and products, services and works. Offers on procedures, methods and approaches
doaj
What Does ‘Experiencing Meaning’ Mean?
, 2017 Wittgenstein links the strange phenomenon of experiencing meaning to the more familiar phenomenon of seeing-as, or noticing an aspect. His interest in the subject seems to have been sparked by the work of William James, and this chapter examines both what he has to say on the matter (some of which long pre-dates the 'third' Wittgenstein stage) and its ...
openaire +2 more sources