Results 91 to 100 of about 166,095,516 (255)

Modern Poets of the Southern Bassarabia

open access: yesJournal of Danubian Studies and Research, 2015
Southern Bassarabiais is inseparable historically from the active creative development. Being in the shadow of major cultural centers, the region is not completely separated.
Alexander Viger
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Role of prosodi's means in expression of the highest degree of the category of quality

open access: yesPolylinguality and Transcultural Practices, 2011
Article is devoted to the role of prosody's means in expression of the highest degree of a sign and to their place in a complex of the language means used to express their value.
N V Sokolova
doaj  

Situational Variability of Means of Expression of Positive Emotions in Modern English

open access: yesИзвестия Южного федерального университета: Филологические науки, 2017
The article investigates situational variability of means of expression of positive emotions in Modern English. This problem is topical for linguistics of emotions, pragma- and sociolinguistics.
Alina K. Kisil
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei [PDF]

open access: yes, 2009
Background: Trypanosomes undergo extensive developmental changes during their complex life cycle. Crucial among these is the transition between slender and stumpy bloodstream forms and, thereafter, the differentiation from stumpy to tsetse-midgut ...
Ross Alan   +22 more
core   +1 more source

THE LINGUOSTYLISTIC FEATURES OF H. SAHYAN'S TRANSLATION OF THE POEM “THE ARMENIANS” BY PEYO YAVOROV [PDF]

open access: yesЕзиков свят
This article is dedicated to the poem “The Armenians” by the famous Bulgarian poet, playwright, and humanist Peyo Yavorov, as well as its Armenian translation by the renowned Armenian poet Hamo Sahyan.
Tamara POGHOSYAN
doaj   +1 more source

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